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All Journal Journal of Advances in Medicine and Pharmaceutical Sciences
Marcecal, Korthiby
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Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Nursing Public Health

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Exploring the Anticancer Potential of Ferula assa-foetida Bioactive Compounds and Molecular Mechanisms in Breast Cancer Treatment Marcecal, Korthiby; Hashemi, Ramin Hazemi; Jafari, Niloofar; Karimi, Mohammad Reza; Pouran, Leila
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 1: May 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0301.695

Abstract

Breast cancer is a major global health issue, with limited treatment options that often come with adverse side effects. Ferula assa-foetida, a medicinal plant known for its anti-inflammatory, antioxidant, and antimicrobial properties, has shown potential as an anticancer agent. This study investigates the anticancer effects of Ferula assa-foetida extracts on breast cancer cell lines (MCF-7 and T47D). The research identifies key bioactive compounds, such as ferulic acid and flavonoids, and explores their molecular mechanisms. In vitro assays, including cytotoxicity assays (MTT and Alamar Blue) and apoptosis detection (Annexin V/PI staining), were conducted to measure cell proliferation and apoptosis induction. Furthermore, PCR and Western blot analyses were used to examine the expression of apoptosis-related genes (p53, Bcl-2, and caspase-3). The results indicate that Ferula assa-foetida extracts significantly inhibit cell growth and induce apoptosis in breast cancer cells. This study provides insights into the potential of Ferula assa-foetida as a complementary treatment for breast cancer and supports further research to evaluate its clinical applicability.
Co-Authors Hashemi, Ramin Hazemi Jafari, Niloofar Karimi, Mohammad Reza Pouran, Leila