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All Journal Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Journal of Advances in Medicine and Pharmaceutical Sciences
Oentari, Octaviana Dyah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Activity Test of Matoa Leaves on Angiotensin II as an Increasing SOD and GPx Oentari, Octaviana Dyah; Peranginangin, Jason Merari; Purwidyaningrum, Ika
Journal of Advances in Medicine and Pharmaceutical Sciences Vol 3 No 2: November 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.jamaps-0302.752

Abstract

The leaves of the matoa are plants that can be used for hypertension. Matoa leaves were assume to have thought to have hypertensive activity because they contain flavonoids (quercetin-3-O-rhamnosida). Flavonoids can lower blood pressure which is modulated by the Renin-Angiotensin-Aldosterone System (SRAA). Was to fine out about the giving process of matoa leaf extract and fractions in increasing levels of SOD and GPx. This research used the maceration method with 96% ethanol solvent and fractionated by liquid-liquid method using n-hexane fraction solvent, ethyl acetate fraction, and water fraction. In this study, 21 male white rats with Wistar strain were divided into 7 groups, group I named as normal control, group II as negative control (CMC-Na 1%), group III as positive control (Irbesartan), and Group IV. (matoa leaf extract), Group V (n-hexane fraction group VI (ethyl acetate fraction) group VII (water fraction). The data obtained were analyzed with the Shapiro Wilk test, Levene's test and ANOVA. The results showed that the matoa leaf extract a dose 300mg/kg BB lower blood pressure in angiotensin II induced rats incrase SOD and GPx levels in the liver induced by Angiotensin II.
Uji Aktivitas Daun Salam (Sizygium poyantha) Sebagai Antihipertensi Pada Tikus Jantan Yang Diinduksi Angiotensin II oentari, octaviana dyah
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 2 (2025): Desember 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i2.285

Abstract

Bay leaves are one of the plants that can be used for hypertension. Matoa leaves are thought to have hypertensive activity because they contain flavonoids. Flavonoids can lower blood pressure modulated by the Renin-Angiotensin-Aldosterone System (RAAS). The purpose of this study was to determine the administration of bay leaf extracts and fractions in lowering blood pressure.  This study used a maceration method with 96% ethanol solvent and fractionated with a liquid-liquid method using n-hexane fraction solvent, ethyl acetate fraction, water fraction. In this study, 21 male white rats of the Wistar strain were used as test animals divided into 7 groups. All groups except the normal group were induced with Angiotensin II. The antihypertensive activity of bay leaf extracts and fractions was observed from the percentage decrease in systolic and diastolic blood pressure. The results showed that bay leaf extract at a dose of 300 mg/kg BW could lower blood pressure in rats induced by angiotensin II.
Co-Authors Ika Purwidyaningrum Jason Merari Peranginangin