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All Journal Jurnal Ilmiah Medicamento Jurnal Kefarmasian Indonesia
Dewi, Ni Kadek Dhea Cipta
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Chemistry Health Professions Medicine & Pharmacology Public Health

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Pengaruh Pemberian Ekstrak Kunyit Putih (Curcuma zedoaria Rocs.) terhadap Aktivitas Superoksida Dismutase (SOD) Udayani, Ni Nyoman Wahyu; Wardani, I Gusti Agung Ayu Kusuma; Dewi, Ni Kadek Dhea Cipta; Lestari, Ketut Sita Citra
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.8498

Abstract

White turmeric is one of the medicinal plants known for its antioxidant properties. This research aims to investigate the antioxidant strength of white turmeric extract (Curcuma zedoaria) by assessing the superoxide dismutase (SOD) activity in an oxidative stress model of white rats (Rattus norvegicus) exposed to cigarette smoke. The study was conducted as an experimental research with a randomized post-test only control group design. Thirty rats were used, divided randomly into six groups: normal control, negative control, positive control, and three treatment groups with extract doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW. The extract was administered daily for 14 days. SOD levels were analyzed using SPSS 26 with the Tukey Post Hoc test. The results showed that the SOD levels in the serum of animals exposed to oxidative stress were 2.71 ng/ml, 2.86 ng/ml, and 3.32 ng/ml at doses of 100 mg/kgBW, 200 mg/kgBW, and 300 mg/kgBW, respectively. The dose of 300 mg/kgBW exhibited the highest antioxidant activity and showed potential to reduce oxidative stress caused by cigarette smoke exposure. This research adds valuable insight into the antioxidant activity of white turmeric ethanol extract and informs the public about its benefits as a natural antioxidant source, particularly in enhancing superoxide dismutase (SOD) activity. It also highlights the potential for white turmeric to be standardized as an herbal product, paving the way for preclinical and clinical trials towards its development as a phytopharmaceutical product.
Formulation and Potency Extract Gel of Citrus Mistletoe Leaves (Dendrophthoe glabrescens (Blakely) Barlow) on Burn Wound Healing Udayani, Ni Nyoman Wahyu; Dewi, Ni Kadek Dhea Cipta
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Second-degree burns require effective topical therapy to accelerate tissue regeneration and prevent infection. Mistletoe leaves (Dendrophthoe glabrescens (Blakely) Barlow) are traditionally used and are known to be rich in secondary metabolites such as flavonoids, saponins, and tannins, which have anti-inflammatory and antioxidant potential. This study aimed to evaluate the effectiveness of an ethanol leaf extract gel of (Dendrophthoe glabrescens (Blakely) Barlow) in healing second-degree burns in white mice (Mus musculus). The gel was formulated at extract concentrations of 5%, 10%, and 15%. A posttest-only control group design was employed, and the extract gel was applied for 14 days. The results demonstrated a significant increase in the percentage of wound healing, particularly at the 15% concentration, which approached the efficacy of the positive control. The flavonoid, saponin, and tannin activities in the (Dendrophthoe glabrescens (Blakely) Barlow) leaf extract play crucial roles in the healing process through anti-inflammatory, antibacterial, and antioxidant mechanisms, as well as by enhancing collagen synthesis. These findings suggest that this extract gel has potential as an effective alternative therapy for burn wounds.
Co-Authors Lestari, Ketut Sita Citra Ni Nyoman Wahyu Udayani Wardani, I Gusti Agung Ayu Kusuma