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All Journal Guruku: Jurnal Pendidikan dan Sosial Humaniora The International Journal of Medical Science and Health Research The Indonesian Journal of General Medicine
Asra Dewita Namora Harahap
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Humanities Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : The Indonesian Journal of General Medicine

 1 
The Analysis Study of Association of Type 2 Diabetes Mellitus and Hepatocellular Carcinoma : A Comprehensive Systematic Review Muhammad Ilham Wira Tri Putra; Asra Dewita Namora Harahap
The Indonesian Journal of General Medicine Vol. 7 No. 4 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/x66ng691

Abstract

Background: Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, and its incidence and mortality have been steadily increasing in recent decades. Numerous studies have shown that individuals with type 2 diabetes are more likely to develop HCC. This systematic review aims to evaluate the association regarding the role of diabetes in the development and progression of HCC based on literatures of the last decade. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: T2DM is a significant risk factor for HCC, especially with metabolic comorbidities. GLP-1RAs show promise in reducing this risk. Public health interventions are needed to improve diabetes management, and further research is essential to validate and explore these findings.
The Analysis Study of Effectiveness and Safety of Rituximab in The Management of Pediatric Systemic Lupus Erythematosus: A Systematic Review Muhammad Ilham Wira Tri Putra; Asra Dewita Namora Harahap
The Indonesian Journal of General Medicine Vol. 9 No. 1 (2025): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/yy7a4p83

Abstract

Background: Pediatric systemic lupus erythematosus (pSLE) is a chronic autoimmune disease with an incidence of 0.3–0.9 per 100,000 children per year. Despite growing interest in RTX as a therapeutic option, its use in pSLE remains off-label, and its efficacy and safety have not been well established in this population. This systematic review aims to assess the effectiveness and safety of RTX in children with pSLE based on literatures of the last decade. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2015 to 2025. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: Rituximab is an effective and well-tolerated treatment for pediatric SLE, reducing disease activity, corticosteroid dependence, and flare-ups. While generally safe, monitoring for infusion reactions and hypogammaglobulinemia is crucial. Early administration may improve outcomes, highlighting its role in refractory pediatric SLE management.
Co-Authors Adit Muhammad Prasetya Hutagalung Muhammad Ilham Wira Tri Putra Rehan Mita Syaputri