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S, Mahral Effendi
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Uji Daya Hambat Ekstrak Etanol Kulit Jeruk Nipis (Citrus aurantifolia (Christm.) Swingle) Sebagai Antibakteri Terhadap Escherichia coli S, Mahral Effendi
Herbal Medicine Journal Vol 4 No 2 (2021): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v4i2.131

Abstract

Diarrhea is one of the public health problems and is a major cause of morbidity and mortality in infants and children. One of the main causes of diarrhea is due to Escherichia coli bacterial infection. Medicinal plants are currently widely used by the community as an alternative treatment because the ingredients are easy to obtain, the price is relatively cheap and the side effects are relatively low compared to synthesized drugs such as lime (Citrus aurantifolia (Christm.) Swingle). The purpose of this study was to determine the effect of ethanol extract of lime peel (Citrus aurantifolia (Christm.) Swingle) on the growth of Escherichia coli bacteria and to determine the potential of ethanol extract of lime peel (Citrus aurantifolia (Christm.) Swingle) as an antibacterial and antibacterial cause of diarrhea. The extraction method with maceration using 96% ethanol solvent, while the antibacterial activity test was carried out using the paper disc diffusion method. The results showed that the ethanol extract of lime peel at concentrations of 10%, 30%, 50% and 70% had inhibition zone diameters of 7.30 mm, 7.48 mm. 8.71 mm and 12.80 mm respectively. The conclusion of this study is that the ethanol extract of lime peel is effective at a concentration of 70% with a strong category.
Efektivitas Ekstrak Etanol Buah Andaliman (Zanthoxylum acanthopodium DC) Sebagai Antibakteri Terhadap Escherichia coli S, Mahral Effendi
Herbal Medicine Journal Vol 5 No 2 (2022): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v5i2.132

Abstract

Zanthoxylum acanthopodium or Andaliman is a wild plant in North Sumatra, Indonesia that has been used as traditional medicine such as treating diarrhea, abdominal pain, dysentery, toothache, leprosy and abscesses. The purpose of this study was to determine the effect of andaliman fruit ethanol extract on the growth of Escherichia coli bacteria and to determine the effective concentration of andaliman fruit ethanol extract as an antibacterial causing diarrhea. The research method is experimental, which is carried out in stages. Extraction using the maceration method while the antibacterial activity test using the paper disc method. The extract concentration consisted of 70%, 50%, 30%, 10%, DMSO as a negative control and amoxicillin as a positive control. The phytochemical screening results consisted of alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids. The results of the antibacterial activity test showed that the ethanolic extract of andaliman fruit had the potential as an antibacterial at each concentration respectively 70%, 50%, 30%, 10% with the diameter of the inhibition zones being 17.28 mm, 14.87 mm, 13.69 mm and 10.35 mm, respectively. strong category. The ethanol extract of andaliman fruit has an effective antibacterial activity at a concentration of 10%.
Validasi Metode Analisa Kadar Fenolik Ekstrak Etanol Patikan Kebo (Euphorbia hirta L) dengan Menggunakan Spectroscopy UV- Vis S, Mahral Effendi
Herbal Medicine Journal Vol 6 No 2 (2023): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v6i2.133

Abstract

Validation research has been carried out on the phenolic content analysis method using the DPPH method on the ethanol extract of Patikan Kebo. In this research, the patikan kebo leaves were previously characterized microscopically and macroscopically and a phytochemical screening test was carried out to determine the secondary metabolite content in the patikan kebo leaves. Next, extraction is carried out using the maceration method. The resulting extract is then analyzed to determine the phenolic content in the sample. Determination of phenolic content uses a method that is first calibrated, which includes linearity, LOD and LOQ, precision, accuracy and sensitivity. The results of each analytical parameter analysis are as follows: linearity = 0.9909, precision = 0.046; 0.06; 0.019 recovery = 98 and 102 %, sensitivity = 1.02. 105 L. Mol-1 cm-1. Analysis of the phenolic sample showed a concentration value of 36.3 mg GAE/gram of patikan kebo extract.
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