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All Journal Journal of Epidemiology and Public Health Indonesian Journal of Cancer
Makbul, Firshan
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Assessing the Potential of Valproic Acid as an Adjuvant Agent among Various Histological Subtypes of Thyroid Cancer: A Systematic Review Makbul, Firshan; Ahani, Ardhi Rahman
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1169

Abstract

Background: Valproic acid (VPA) has gained attention as an anticonvulsant drug with potential anti-cancer effects, including in thyroid cancer. It hampers the viability of cancer cells by blocking their cell cycle progression, specifically in the G1 or sub-G1 phases. However, the clinical role of VPA as an adjuvant agent, in addition to the thyroid cancer primary treatment, remains an area of investigation.Methods: We conducted a comprehensive systematic literature review from the first publication available to July 2021. We comprised clinical trials and preclinical investigations that explored VPA’s underlying mechanisms and treatment strategies in thyroid cancer.Results: Fifteen eligible studies were included. Thirteen preclinical studies revealed that VPA significantly enhances therapeutic responses across various histological subtypes of thyroid cancer cells. Regarding clinical implications, recent clinical studies indicated no significant effect on tumor response or overall survival.Conclusions: Our findings highlight the key role of VPA as an alternative therapeutic strategy for thyroid cancer, considering its favorable impact on various histological subtypes. Further welldesigned studies in clinical settings are required to identify the knowledge gap regarding its use in other multimodal treatments such as chemotherapy, surgery, and radiotherapy.
Incidence of Tuberculosis in Primary Health Care during the COVID-19 Pandemic: A Longitudinal Study and Perspective from Eastern Indonesia Makbul, Firshan; Amir, Darmawati
Journal of Epidemiology and Public Health Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.01.11

Abstract

Background: Efforts to fight tuberculosis (TB) infection requires a deep understanding of disease control trends to consistently sustain and enhance the identification and treatment of at-risk populations. Indonesia is the third highest globally in TB cases, followed by India and China, accounting for about 10% of all cases. Over the past ten years, Indonesia has witnessed significant TB case reporting and treatment coverage growth. This study aimed to analyze TB case occurrences in a primary health-care setting during the COVID-19 pandemic.Subjects and Method: A cross-sectional study, which included data from the Puskesmas Lau reports from July 2021 to July 2022. A total of 71 patients were conducted using the total sampling method. The collected data were processed descriptively to summarize participants' demographic characteristics and clinical profiles and various important indicators from WHO were analyzed to determine its effectiveness.Results: The center's tuberculosis screening efforts have not reached their optimal level, falling below the national standard of ≥70% for the Case Detection Rate (CDR). However, the treatment success rate (SR) exceeds 90%.Conclusion: The evaluation of the TB control program at Puskesmas Lau reveals achievements in some areas but also highlights challenges posed by the pandemic and the need for strengthened strategies to improve case detection and management. Perceived vulnerability, seriousness, benefit, and barrier, as well as the availability of DOTS treatment, affect treatment adherence. Partnership between patients and health care personnel is recommended to increase the success of TB treatment. Keywords: Tuberculosis, primary health care, COVID-19, longitudinal study, health services
Incidence of Tuberculosis in Primary Health Care during the COVID-19 Pandemic: A Longitudinal Study and Perspective from Eastern Indonesia Makbul, Firshan; Amir, Darmawati
Journal of Epidemiology and Public Health Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2024.09.01.11

Abstract

Background: Efforts to fight tuberculosis (TB) infection requires a deep understanding of disease control trends to consistently sustain and enhance the identification and treatment of at-risk populations. Indonesia is the third highest globally in TB cases, followed by India and China, accounting for about 10% of all cases. Over the past ten years, Indonesia has witnessed significant TB case reporting and treatment coverage growth. This study aimed to analyze TB case occurrences in a primary health-care setting during the COVID-19 pandemic.Subjects and Method: A cross-sectional study, which included data from the Puskesmas Lau reports from July 2021 to July 2022. A total of 71 patients were conducted using the total sampling method. The collected data were processed descriptively to summarize participants' demographic characteristics and clinical profiles and various important indicators from WHO were analyzed to determine its effectiveness.Results: The center's tuberculosis screening efforts have not reached their optimal level, falling below the national standard of ≥70% for the Case Detection Rate (CDR). However, the treatment success rate (SR) exceeds 90%.Conclusion: The evaluation of the TB control program at Puskesmas Lau reveals achievements in some areas but also highlights challenges posed by the pandemic and the need for strengthened strategies to improve case detection and management. Perceived vulnerability, seriousness, benefit, and barrier, as well as the availability of DOTS treatment, affect treatment adherence. Partnership between patients and health care personnel is recommended to increase the success of TB treatment. Keywords: Tuberculosis, primary health care, COVID-19, longitudinal study, health services
Co-Authors Ahani, Ardhi Rahman Amir, Darmawati