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Muhammad hafiz adha
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Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Inovasi Eksipien Untuk Tablet Cepat Hancur Muhammad hafiz adha; Nita Rahmadani; Anisa Nazwa; Khairatunnisa; Siti Noorlena
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1788

Abstract

The main objective of this study is to review and explore various innovations in excipient materials used in the development of fast disintegrating tablets (FDT). This research utilizes the Systematic Literature Review (SLR) method, which is a comprehensive approach to systematically collect and analyze relevant literature. The results of the research indicate that overall, various studies have shown that innovations in tablet formulation, including excipient materials, production techniques, and drug delivery systems, significantly impact the effectiveness and comfort of drug use. The use of appropriate excipients, such as Biotapioka, avocado seed starch, and new technologies like edible paper and freeze drying, has been proven to address issues related to poor drug solubility and dissolution. With the right formulation, it is possible for tablets to disintegrate more rapidly in the mouth, allowing patients to experience the benefits of the medication more quickly, without the need for water or difficulty swallowing large tablets. This is especially important for patients who have trouble swallowing pills, such as the elderly, children, or patients with certain medical conditions.
Uji Stabilitas Fisik dan Kimia Sediaan Tablet Paracetamol terhadap Suhu dan Kelembaban Selama Penyimpanan Muhammad Hafiz Adha; Jaida Rahma; Nor Latifah
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3034

Abstract

This study aims to evaluate the physical and chemical stability of paracetamol tablets under varying temperature and humidity conditions, specifically room temperature (25°C ± 2°C) and high temperature (40°C ± 2°C) with relative humidity of 75% ± 5%. The stability test was conducted over a period of three months with observations at 30-day intervals. Parameters assessed included changes in color, tablet hardness, active ingredient content (measured using UV-Vis spectrophotometry), and pH of the dissolved solution. The results showed that tablets stored at high temperature experienced a decrease in paracetamol content by up to 5.8% and visible color changes starting from the second month. These findings highlight the importance of proper storage conditions to maintain the quality, safety, and efficacy of pharmaceutical products.
Co-Authors Anisa Nazwa Jaida Rahma Khairatunnisa Nita Rahmadani Nor Latifah Siti Noorlena