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All Journal Jurnal Ilmiah Farmasi JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit)
Ha, Hai-Anh
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Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Nursing Public Health

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Bioinformatics analysis of radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma for COVID-19 treatment Hoang, Thi-Van; Nguyen, Chi-Cong; Nguyen, Thi-Thuy-An; Pham, Thi-Thuy-Linh; Nguyen, Phan-Anh; Nguyen, Trang-Thuy; Ha, Hai-Anh
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art1

Abstract

Background: The COVID-19 pandemic, which has unfolded over the past years, poses significant threats to global public health and socioeconomic well-being. Three herbs (radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma) have been long utilized in combination for treating common colds and flu.Objective: To analyze potential biotargets and explore possible effects of plant-derived compounds from 3 herbs towards COVID-19 treatment.Method: Bioinformatics databases and network pharmacology were employed to identify bioactive compounds and their biotargets with integrated statistical calculation, followed by Gene Ontology enrichment. KEGG pathway analysis was performed to elucidate the involvement of selected bioactive compounds in COVID-19-related processes.Results: Network pharmacology highlighted essential receptors, cytokines, and signaling proteins. Gene Ontology analysis revealed associations with signal transduction, RNA transcription enzymes, and crucial cellular components. Molecular function analysis emphasized interactions related to virus entry. KEGG analysis uncovered 32 potential targets across various pathways, elucidating their role in inflammation and cytokine storms. Conclusion: This study provides new insight for the molecular mechanisms underlying the therapeutic potential of a combination of radix Angelica dahurica, Chuanxiong rhizoma, and Cyperi rhizoma against COVID-19. The identified targets and pathways offer new directions for further experimental validation, paving the way for potential therapeutic interventions for COVID-19.
Cost Analysis of Parturition with Sectio Caesarea at PKU Muhammadiyah Yogyakarta, Indonesia Hospital Based on INA-CBG’s Tariff in 2023 Hadning, Ingenida; Yumna, Nurina Faridah; Viviandhari, Daniek; Taufani, Indra Putra; Ha, Hai-Anh
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol. 14 No. 2 (2025): August 2025
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.v14i2.552

Abstract

The 2018 Riskesdas results showed that the prevalence of delivery by sectio caesarea in DIY was 23.1%. The high cost of sectio caesarea hinders access to public health, so the government implemented the INA-CBG's tariff. This study is the first to evaluate the INA-CBG's tariff based on the Permenkes RI Number 3 of 2023 for inpatient sectio caesarea delivery. This study aims to determine the difference between the cost of sectio caesarea delivery and the INA-CBG's tariff based on Permenkes RI Number 3 of 2023. Through this research, hospitals are expected to evaluate their services so that the costs of cesarean sections are under the INA-CBG's tariff. In addition, this research can serve as an evaluation of the INA-CBG's tariff for the government. This study used observational research methods and a cross-sectional approach. Data were obtained retrospectively by tracing medical records and treatment cost data of sectio caesarea patients from January to September 2023. Data were analyzed by descriptive analysis, one-sample t-test and one-sample Wilcoxon methods. The results of this study showed that the average actual cost was greater than the INA-CBG's rate, with significant differences in patients with class I code O-6-10-I, class II codes O-6-10-I and O-6-10-II, and class III code O-6-10-II, so that PKU Muhammadiyah Yogyakarta Hospital suffered losses.
Anticancer chemotherapies targeting Wnt/β-catenin signaling pathway: a review on molecular insights Nguyen, Thi Quynh Huong; Tran, Thi-Kieu-Trinh; Nguyen, Vu-Quynh-Nhu; Pham, Thuy-Loc; Nguyen, Thi-Thuy; Ngo, Thi-Kieu-Diem; Vu, Thi-Tram; Pham, Thi-Phuong-Thao; Ha, Hai-Anh
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art4

Abstract

Background: The Wnt/β-catenin signaling pathway, a highly conserved signaling axis involved in diverse physiological processes such as proliferation, differentiation, apoptosis, migration, invasion, and homeostasis balance, has been implicated in human cancer development and progression. Notably, various cancer types, such as colorectal cancer, hepatocellular carcinoma, melanoma, thyroid cancer, desmoid tumors, ovarian tumors, and multiple myeloma, have demonstrated associations with specific Wnt-activating mutations, emphasizing the widespread influence of the Wnt pathway in diverse malignancies. Objective: This review highlights the inhibitors targeting the Wnt ligand-receptor interface, focusing on their preclinical and clinical evaluations in various cancer types. Additionally, we explore small-molecule design strategies, focusing on inhibitors of β-catenin, GSK-3, and Porcupine. Method: Conducted as a narrative review, we collected and analyzed relevant papers from PubMed/Google Scholar and clinical trials associated with Wnt pathway inhibitors from clinicaltrial.gov. A total of 61 papers and 24 clinical trials were reviewed, providing an overview of the molecular insights within the research landscape of this field. Result: Dysregulated Wnt/β-catenin signaling is implicated in the progression of several solid tumors and hematological malignancies, highlighting the urgent need for targeted anticancer interventions. Our discussion on the inhibitors targeting the Wnt ligand-receptor interface highlights promising outcomes in both preclinical and clinical settings. This paper also presents the chemical structures of these compounds, detailing their interactions with key Wnt signaling components and their potential to disrupt aberrant signaling. The strategies for small-molecule design targeting the Wnt signal are discussed, highlighting inhibitors targeting β-catenin, GSK-3, and Porcupine. The complex chemical structures of these compounds are elucidated, showcasing their specific interactions with key components of the Wnt signaling pathway and their potential to disrupt aberrant Wnt signaling in diverse cancer types. The emerging directions and future prospects in Wnt pathway research demonstrate the importance of utilizing big data and artificial intelligence for drug development. Conclusion: The review delves into the potential inhibition of the disheveled protein as a promising target for cancer therapy, proposing novel molecular design strategies based on recent discoveries. Keywords: Wnt signaling pathway, β-catenin inhibitors, GSK-3 inhibitors, porcupine inhibitors, Disheveled protein inhibitors
Co-Authors Hoang, Thi-Van Ingenida Hadning Ngo, Thi-Kieu-Diem Nguyen, Chi-Cong Nguyen, Phan-Anh Nguyen, Thi Quynh Huong Nguyen, Thi-Thuy Nguyen, Thi-Thuy-An Nguyen, Trang-Thuy Nguyen, Vu-Quynh-Nhu Pham, Thi-Phuong-Thao Pham, Thi-Thuy-Linh Pham, Thuy-Loc Taufani, Indra Putra Tran, Thi-Kieu-Trinh Viviandhari, Daniek Vu, Thi-Tram Yumna, Nurina Faridah