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All Journal Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Jurnal Kedokteran Meditek
Swantari, Ni Made
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Kapasitas Antioksidan Ekstrak Batang Brotowali (Tinospora crispa L.) dengan metode ABTS, DPPH, dan FRAP Soebrata, Linginda; Swantari, Ni Made; Ferdinal, Frans; Yulianti, Eny
ANATOMICA MEDICAL JOURNAL | AMJ Vol 9, No 1 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v9i1.27669

Abstract

Antioksidan banyak terkandung dalam tanaman, terutama tanaman herbal. Batang brotowali (Tinospora crispa L.) merupakan salah satu tanaman herbal yang memiliki potensi antioksidan. Kapasitas antioksidan dapat bervariasi tergantung dari metode yang digunakan. Oleh karena itu, pada penelitian ini, penulis bertujuan untuk menentukan kapasitas antioksidan ekstrak batang brotowali dengan berbagai metode. Penelitian dilakukan menggunakan metode DPPH, ABTS, dan FRAP, dengan metanol sebagai pelarutnya. Hasil didapatkan bahwa metode FRAP menghasilkan nilai IC50 yang paling rendah yaitu 17.08 µg/mL, dengan hasil ABTS dan DPPH berturut – turut sebagai berikut 38.63 µg/mL, 245.95 µg/mL, sehingga dapat disimpulkan bahwa batang brotowali memiliki aktivitas antioksidan yang bervariasi antara kuat hingga lemat bergantung pada metode yang digunakan. Hasil paling tinggi ditemukan pada metode FRAP.Kata kunci: ABTS, antioksidan, DPPH, FRAP
Analisis Kandungan Fitokimia, Fenolik, Aktivitas Antioksidan, dan Toksisitas Daun Kumis Kucing Aspasia, Ariadne Calista; Swantari, Ni Made; Ferdinal, Frans; Yulianti, Eny
Jurnal Kedokteran Meditek Vol 32 No 3 (2026): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i3.3818

Abstract

Introduction: Orthosiphon stamineus (cat’s whiskers) is a traditional medicinal plant rich in bioactive compounds and has potential as a natural antioxidant. However, comprehensive studies linking its phytochemical composition with antioxidant activity and toxicity remain limited. Purpose: This study aimed to evaluate the phytochemical profile, total phenolic content, antioxidant activity, and toxicity of O. stamineus leaf extract. Methods: The study was conducted experimentally using in vitro and bioassay approaches. Phytochemical screening was performed to identify secondary metabolites. Total phenolic content was determined using the Folin–Ciocalteu method with gallic acid as the standard. Antioxidant activity was assessed using DPPH, ABTS, and FRAP assays, while toxicity was evaluated using the Brine Shrimp Lethality Test (BSLT). Results: The results showed that the extract contained various secondary metabolites, including alkaloids, flavonoids, coumarins, tannins, phenolics, terpenoids, steroids, glycosides, quinones, anthocyanins, and cardiac glycosides. The total phenolic content was 43.02 mg GAE/g DW. The IC₅₀ values for DPPH and ABTS were 116.29 µg/mL and 123.22 µg/mL, respectively, indicating moderate antioxidant activity. The FRAP value was 337.9 µmol/L. Toxicity testing yielded an LC₅₀ value of 653.6 µg/mL, indicating low toxicity. Conclusion: O. stamineus leaf extract shows potential as a natural antioxidant source with low toxicity, supporting its prospective application in pharmaceutical and health-related fields.
Co-Authors Aspasia, Ariadne Calista Eny Yulianti, Eny Frans Ferdinal Soebrata, Linginda