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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Medical Studies
Evi Supriadi
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Other

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Folic Acid Supplementation for Blood Pressure Reduction in Hypertension: A Meta-Analysis Harqiqi, Andreafika Kusumaningtyas; Evi Supriadi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1134

Abstract

Background: Hypertension is a major risk factor for cardiovascular disease. While antihypertensive medications are the cornerstone of treatment, adjunctive therapies like folic acid supplementation have gained attention for their potential to lower blood pressure. This meta-analysis aims to comprehensively assess the impact of folic acid supplementation on blood pressure in hypertensive individuals. Methods: A systematic search of electronic databases (PubMed, Embase, Cochrane Library) was conducted from January 2018 to December 2023 to identify randomized controlled trials (RCTs) evaluating the effect of folic acid supplementation on blood pressure in adults with hypertension. Data on systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were extracted. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Twenty-three RCTs involving 2,853 hypertensive participants were included. Folic acid supplementation was associated with a significant reduction in SBP (mean difference [MD] -2.93 mmHg, 95% confidence interval [CI] -4.11 to -1.75, p < 0.00001), DBP (MD -1.87 mmHg, 95% CI -2.63 to -1.11, p < 0.00001), and MAP (MD -2.21 mmHg, 95% CI -3.01 to -1.41, p < 0.00001) compared to placebo or control. Subgroup analyses revealed that the blood pressure-lowering effect of folic acid was more pronounced in individuals with low baseline folate levels, those with higher baseline blood pressure, and in studies with longer durations of supplementation. Conclusion: Folic acid supplementation appears to be a safe and effective adjunctive therapy for reducing blood pressure in hypertensive individuals. These findings support the potential role of folic acid in improving cardiovascular outcomes in this population.
The Relationship between Leukocyte Count and Left Ventricular Ejection Fraction in Patients with ST-Elevation Myocardial Infarction Muhammad Atha Muafa; Evi Supriadi; Fairuz; David Ramli; Hasna Dewi
Journal of Medical Studies Vol. 5 No. 1 (2025): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v5i1.43281

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ABSTRACT Background: ST-Elevation Myocardial Infarction (STEMI) causes significant myocardial damage and increases heart failure risk. Inflammation, reflected by leukocyte count, is considered to play a crucial role in STEMI's pathophysiology, potentially affecting cardiac function. This study aimed to evaluate the relationship between leukocyte count and left ventricular ejection fraction (LVEF) in STEMI patients. Methods: A cross-sectional study was conducted from August to September 2024 at RSUD Raden Mattaher Jambi. Data from 80 patient medical records, including leukocyte count at admission and LVEF measured via echocardiography, were analyzed using Fisher's Exact and Spearman's correlation tests. Results: Most patients were male (82.5%), with high leukocyte counts (67.5%) and low LVEF (82.5%). The mean age was 57.8 years. Prevalences of hypertension, diabetes, and dyslipidemia were 38.8%, 33.8%, and 47.5%, respectively. Statistical analysis revealed no significant relationship between leukocyte count and LVEF (Fisher's p=0.497; Spearman's p=0.078; r=0.16). Conclusion: This study found no significant association between leukocyte count and LVEF in STEMI patients. Keywords: STEMI; Leukocyte; Ejection fraction
Co-Authors David Ramli Fairuz Harqiqi, Andreafika Kusumaningtyas Hasna Dewi Muhammad Atha Muafa