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All Journal Solo Journal of Anesthesi, Pain and Critical Care Jurnal Komplikasi Anestesi
Fitriani R.W, Calcarina
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Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Nursing Public Health

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Thromboprophylaxis in Intensive Care Unit Patients Rikardi, Fachrizal; Fitriani R.W, Calcarina
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 4, No 2 (2024): October 2024
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v4i2.93687

Abstract

Background: Intensive Care Unit (ICU) patients are at twice the risk of experiencing thrombosis compared to patients in regular wards. This risk is associated with prolonged immobility, sedation, and neuromuscular blockade to facilitate ventilation. The incidence ranges from 8-40%. This undoubtedly leads to poorer patient outcomes, including increased patient mortality. ICU patients require prophylaxis to prevent thrombotic events. The use of thromboprophylaxis has been shown to reduce mortality rates in these patients.Content: Intensive Care Unit (ICU) patients are at risk of developing thrombosis, which is closely related to Virchow's triad, which consists of venous stasis, endothelial dysfunction, and hypercoagulability. Considering the high morbidity associated with thrombotic events and the low side effects of carefully administered anticoagulants, pharmacological prophylaxis should be provided to all critically ill patients without contraindications to anticoagulants. Regular monitoring is necessary when administering pharmacological prophylaxis. Compared with UFH and mechanical compression, LMWH is the preferred thromboprophylaxis for ICU patients. Generally, patients weighing 50-100 kg can be given LMWH, such as enoxaparin, at a subcutaneous dose of 40 mg per day. The discontinuation of thromboprophylaxis should consider the patient's clinical condition and drug side effects.Summary: Thromboprophylaxis is highly necessary for Intensive Care Unit (ICU) patients. The preferred thromboprophylaxis for ICU patients is LMWH. In certain circumstances, UFH or mechanical thromboprophylaxis may be considered.
english English Pasmawati, Desti; Fitriani R.W, Calcarina; Adiyanto, Bowo
Jurnal Komplikasi Anestesi Vol 13 No 2 (2026)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v13i2.28917

Abstract

Background : Sepsis is one of the causes of morbidity and mortality patients hospitalized in the intensive care unit (ICU) which requires early detection and management to predict outcomes. Lactate-albumin ratio has a predictive value of mortality in patient with sepsis that is similar to APACHE II and SOFA scores. Objective : To determine the relationship between the lactate-albumin ratio and mortality and length of stay patient with sepsis in ICU of Dr. Sardjito Hospital. Method : Research design using a retrospective cohort observational study by collecting data from the medical records of sepsis patients at ICU of Dr. Sardjito Hospital. Data were calculate the optimal cutoff using the ROC curve. The relationship between lactate-albumin ratio levels and mortality was analyzed using the chi-square test method followed by logistic regression. Results : The total study subjects were 136 patients. The cut-off value for the Lactate-Albumin ratio in predicting mortality 0,878, sensitivity 73.0 % and specificity 57.1% (AUC = 0,687; 95% CI 0,56-0,81; p=0,007). The cut-off value for the Lactate-Albumin ratio in predicting ICU length of stay 0,878, sensitivity 71,2% and specificity 63,6% (AUC = 0,684; 95% CI 0,53-0,84; p=0,043). Multivariate analysis showed that an increase in the Lactate-Albumin ratio was independent and significant factor as a predictor of mortality (OR=3,43; 95% CI 1,29-9,16; p=0,013) and ICU length of stay (OR=4,33; 95% CI 1,19-15,68; p=0,036). Conclusion : An increase in the Lactate-Albumin ratio is independently and significantly associated with an increased risk of mortality and length of stay in sepsis patients.
Co-Authors Bowo Adiyanto Pasmawati, Desti Rikardi, Fachrizal