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All Journal Althea Medical Journal Hexagon
Amalia, Nuri
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Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Medicine & Pharmacology

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Recombinant Tissue Plasminogen Activator (rtPA) Affects Extremity Motor Progress in Acute Ischemic Stroke Patients Ramadhani, Dhianty; Amalia, Nuri; Putri, Mirasari
Althea Medical Journal Vol 11, No 4 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n4.3364

Abstract

Background: Decreased motor function is the most common disorder caused by stroke, leading to disability. Early recanalization is the potential therapy for acute ischemic stroke, by using recombinant tissue plasminogen activator (rtPA). This study aimed to analyze the effectiveness of rtPA therapy on the motor progression of extremities in acute ischemic stroke patients.Methods: This was a retrospective cohort study using secondary data from medical records of 45 patients with acute ischemic stroke who received rtPA therapy in Al Islam Bandung Hospital, Indonesia in 2022. The limb motor progress was designated as an increase in strength motoric function skills of the left and right arms, as well as the left and right legs which were influenced by the neuroplasticity process. Marginal homogeneity test was used with significance at p<0.05.Results: Therapy of rtPA improved affected limb motor progress in patients (p=0.000). Before the administration of rtPA, all patients experienced muscle weakness. After 24 hours of rtPA therapy, patients experienced a decrease in muscle strength (9.5%), a steady state (28.6%), and increased in muscle strength (61.9%). After 72 hours, it was found that patients experienced a decrease in muscle strength (9.5%), a steady state (16.7%), and  increased in muscle strength (76.2%).Conclusion: Administration of rtPA significantly affects the progress of limb motor improvement in acute ischemic stroke patients. This study supports rtPA as a? primary therapeutic option for acute ischemic stroke patients and is expected to contribute to improving the management and recovery of stroke, a critical illness associated with aging.
BIOSINTESIS LAPISAN TIPIS ZnO MENGGUNAKAN EKSTRAK TEMU KUNCI (BOESENBERGIA PANDURATA) DENGAN METODE SPIN COATING: VARIASI WAKTU PERTUMBUHAN Amalia, Nuri; Yanuar, Emsal; Suhaimi, Lalu
Hexagon Vol 4 No 2 (2023): HEXAGON - Edisi 8
Publisher : Fakultas Teknologi Lingkungan dan Mineral - Universitas Teknologi Sumbawa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36761/hexagon.v4i2.3025

Abstract

ZnO merupakan salah satu material yang banyak dikembangkan oleh peneliti karena sifatnya yang unik seperti fotokatalitik, elektrik, optik, dan antibakteri. Artikel ini memuat penelitian dalam melakukan biosintesis ZnO nanopartikel menggunakan ekstrak temu kunci dengan metode spin coating pada variasi waktu pertumbuhan. Proses diawali dengan pembuatan larutan bibit dengan konsentrasi 0,5M pada temperatur 60? dengan kecepatan 1000rpm selama 60 menit. Selanjutnya, pembuatan lapisan bibit dengan teknik spin coating. Lapisan tipis ZnO nanostruktur ditumbuhkan dengan variasi waktu 3 jam dan 4 jam. Hasil analisis SEM menunjukkan bentuk morfologi ZnO di atas substrat kaca berbentuk spherical dan terjadi aglomerasi pada masing-masing variasi. Ukuran rata-rata butir ZnO pada perlakuan waktu tumbuh 3 jam adalah 88.61 nm dan 4 jam adalah 58.23 nm. Hasil analisis pola XRD menunjukkan bahwa dari masing- masing sampel ZnO memiliki kristalinitas tinggi berbentuk heksagonal, dengan. ukuran kristal pada waktu tumbuh dari 3 jam yaitu 25.8 nm dan 4 jam sebesar 34.4 nm. Nilai Energy gap pada waktu pertumbuhan 3 jam adalah 3.40eV dan 4 jam adalah 3.85 eV. Nilai absorbansi relatif tinggi pada perlakuan 3 jam dengan panjang gelombang 215 dan pada perlakuan 4 jam dengan panjang gelombang 245nm.
Co-Authors Ramadhani, Dhianty Yanuar, Emsal