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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Wicara Desa
Vitri, Desy Aryanti Pardilla
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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In Vitro Mucolytic Activity of Cardamom Fruit (Amomum compactum) Decoction on Duck Egg Albumens Vitri, Desy Aryanti Pardilla; Aini, Siti Rahmatul; Saputri, Legis Ocktaviana
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.541-547

Abstract

Cardamom (Amomum compactum) is empirically used as a cough medicine by using its seeds and fruits. Cardamom seeds have been shown to have mucolytic activity at a concentration of 0.8%, while cardamom fruit has not been studied. This study aimed to determine the mucolytic activity of cardamom fruit decoction at variation concentrations. Mucolytic activity tests were carried out in vitro on duck egg albumens at 3%, 6%, and 12% variation concentrations of cardamom fruit decoction. N-acetylcysteine 0.1% was positive control, while phosphate buffer and Tween 80 were negative controls. The mucolytic activity was determined based on the viscosity value measured by flow time using an Ostwald viscometer and density measurement using a pycnometer. Data from each group were analyzed using SPSS with parametric One-Way ANOVA and Post Hoc tests. The results showed that cardamom fruit decoction at concentrations of 3%, 6%, and 12% had values that were not significantly different from N-acetylcysteine (p>0.05) and there was no significant difference (p>0.05) between each concentration group. Accordingly, the research concludes that cardamom fruit decoction at concentrations of 3%, 6%, and 12% has mucolytic activity comparable to N-acetylcysteine.
Co-Authors Afdhalu, Ahmad Naufal Aini, Siti Rahmatul Akbari, Gilang Zulfa Ardira, Rizki Desima Artapati, Lalu Insan, Rofi Akhlakul Nada, Lisa Katun Ocktaviana Saputri, Legis Rijal, Siti Khairun Hafizo Yanti, Arnita Yasmin Yasmin