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All Journal JURNAL PHOTON Jurnal Media Informatika
Ya’la, Fitra Audhi
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Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Nursing Physics

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Antidepressant-like Effects of Young Areca Nut n-Hexane Extract Using Forced Swim Test in Mice Tested Individually Novianty, Riryn; Yuharmen, Yuharmen; Sofiyanti, Nery; Ya’la, Fitra Audhi
Jurnal Media Informatika Vol. 5 No. 3 (2024): Jurnal Media Informatika Edisi Mei - Agustus
Publisher : Jurnal Media Informatika

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Abstract

Depression is a common neuropsychiatric disorder that occurs in humans regardless of gender and age. Areca catechu, as a local plant, can be utilized as an antidepressant to treat depression. The current investigation aimed to determine the antidepressant action from an n-hexane extract of young areca nut using the Forced Swim Test (FST) as a standard method in screening antidepressants validated by the behavior of animals. Short-term medication or acute FST was performed by injecting mice with extract at doses 10 and 50 mg/kg, while the mice were treated with the best dose in long-term medication or sub-chronic FST. A day after the re-test on sub-chronic FST, toxicity test was performed. The extract at the dose of 50 mg/kg possessed antidepressant action during acute and sub-chronic FST. The results of the phytochemical analysis stated that the saponins and steroids present in the young areca nut n-hexane extract may be the active constituents that act as antidepressants. No toxic effects were detected from the young areca nut n-hexane extract in mice that had been injected for 7 consecutive days. n-Hexane extract from young areca nut presents antidepressant potential.
Nut in Swiss Albino Mice Independently Assessed by the Forced Swim Test Novianty, Riryn; Yuharmen, Yuharmen; Sofyanti, Nery; Ya’la, Fitra Audhi
Photon: Jurnal Sain dan Kesehatan Vol. 15 No. 2 (2025): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v15i2.9294

Abstract

Depression is a global mental health issue and herbal antidepressants are increasingly sought due to the side effects of synthetic drugs. The present study aimed to evaluate the potential of ethyl acetate extract of old areca nut in treating depression of mice subjected to acute and sub-chronic Forced Swim Test (FST). Ethyl acetate extract was injected intraperitoneally 1 h before the FST at a dose of 50 and 100 mg/kg. The 100 mg/kg dose showed the greatest reduction in immobility time (22.29%) during acute testing. Following seven days of treatment, it was discovered that the extract significantly alleviated the immobility time in sub-chronic FST. The results of the phytochemical analysis showed that phenolics present in the ethyl acetate extract are probably active constituents with antidepressant properties. After prolonged administration, the substance has no toxic effects on the bodies of test animals.
Co-Authors Nery Sofiyanti Novianty, Riryn Sofyanti, Nery Yuharmen, Yuharmen