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All Journal JOURNAL LA MEDIHEALTICO Al Makki Health Informatics Journal
Prasasty, Vony Intan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Literature Review: Analysis of Saponins in Several Plants by HPLC Method and Its Utilization in Pharmaceutical Products Prasasty, Vony Intan
Journal La Medihealtico Vol. 5 No. 6 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i6.1705

Abstract

This research aims to determine the content of saponin compounds found in several types of plants and their benefits for health. This research uses computer equipment and the Google Scholar database, Research Gate, NJC journal, Science Direct. The type of research used is an article review using data sources directly collected by the researcher. The data search was carried out through a Google Scholar database, using the keywords "saponin levels and HPLC". The screening results that met the requirements were used as references for 25 articles. This research used plant samples using the dried leaves of the plant and then extracted using the ultrasonication method, then using centrifugation to obtain a clear solution. The saponin analysis of the samples was carried out. Using HPLC with various columns. From these results, the saponin compound was shown to appear at a retention time of 53.09 minutes with an avarage saponin amount of 1.05%. Pharmacological studies show that saponins have many important such as enhancing immunity, antitumor, anti-inflammatory, antifungal, and anti-viral actions, reducing blood glucose and lipids, antioxidants, improving cardiovascular function. From the results of research conducted by several researchers above, it can be concluded that saponin analysis in several plants can be carried out using HPLC with a wavelength of 205nm. Saponin compounds as secondary metabolites have many benefits in the pharmaceutical field, including anti-inflammatory, hepatoprotective activity, immunological improvement, anti-tumor, anti-aging, treatment of cerebral edema, lung injury, myocardial ischemia reperfusion injury and gastric ulcers.
Phytochemical Screening Of Saponin And Antibacterial Activity Of 96% Ethanol Extract Of Costus Speciosus Against E. Coli And S. Aureus Prasasty, Vony Intan; Prima, Sylvia Rizky; Damayantie, Wury
Al Makki Health Informatics Journal Vol. 3 No. 4 (2025): Al Makki Health Informatics Journal
Publisher : Al Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/hij.v3i4.56

Abstract

This study aims to explore the content of secondary metabolite compounds, especially saponins, and to examine the antibacterial activity of ethanol extract of 96% of unsalted pacing leaves (Costus speciosus) against Escherichia coli and Staphylococcus aureus bacteria. Extraction was carried out by maceration method using 96% ethanol solvent, followed by qualitative phytochemical tests to detect the presence of bioactive compounds. The antibacterial activity test was carried out using the disc diffusion method with various concentrations of extracts (5%, 10%, 20%, 40%, and 80%). The results of phytochemical screening showed that the extract contained saponins, alkaloids, tannins, and triterpenoid compounds, while flavonoids were not detected. Antibacterial tests showed that the extract had concentration-dependent increased bacterial growth inhibition activity, with the highest inhibition zone recorded at 80% concentrations against both test bacteria. The Minimum Inhibitory Concentration (MIC) is set at a concentration of 5%, although significant effectiveness is seen starting at concentrations of 10% and above. Based on these findings, it can be concluded that ethanol extract of 96% unsalted pacing leaves has potential as a natural antibacterial agent, which can be further developed as a candidate for local plant-based phytopharmaceuticals. These findings also make a scientific contribution to the utilization of biological resources in supporting alternative medicine in the era of antibiotic resistance.
Co-Authors Damayantie, Wury Prima, Sylvia Rizky