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All Journal Journal of Biotechnology and Natural Science Journal of Pharmaceutical (JOP)
Pratama, Nofran
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Formulation of Antibacterial Liquid Soap Based on Butterfly Pea Flower (Clitoria ternatea L.) Extract with Ultrasound-Assisted Extraction Technique Pratama, Nofran; Rahayu Purnomo Sari, Kurnia; Rahayu, Budi
Journal of Biotechnology and Natural Science Vol. 4 No. 2 (2024): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i2.12040

Abstract

Butterfly pea flower (Clitoria ternatea L.) exhibits antibacterial properties due to bioactive compounds like phenolics and flavonoids. These compounds were extracted using the UAE (Ultrasound Assisted Extraction) method, which is more efficient than conventional methods. This study aims to address antibacterial resistance by formulating an antibacterial liquid soap using butterfly pea flower extract as the active ingredient. Results showed the liquid soap demonstrated good antibacterial activity and physical stability; however, its pH exceeded skin safety standards. A favorability test involving 20 respondents indicated positive responses regarding texture, aroma, and skin-softening effects. In conclusion, liquid soap containing butterfly pea flower extract has potential as an effective antibacterial product but requires pH improvement to enhance safety.    
Penentuan Kadar Fenolik Total Dan Peredaman Radikal Bebas Ekstrak Metanol Daun Bayam Hijau (Amaranthus hybridus L) Dengan DPPH Nurhasanah, Devika; Mafa , Sutri Hud; Pratama, Nofran
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 2, Special Edition (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i2, Special Edition.1477

Abstract

Background: Free radicals are molecules that have one or more free or unpaired electrons, so that free radicals are unstable. Free radicals can be inhibited in the presence of antioxidant compounds. The compound antioxidant can be obtained from various sources, one of which is from the green spinach plant. Amaranthus hybridus L. is a herbaceous plant from the Amaranthaceae family that contains natural antioxidant compounds, namely phenolic compounds. Objective: This study aimed to determine the total phenolic levels contained in methanol extract of Amaranthus hybridus L. and what is the value of IC50 methanol extract of Amaranthus hybridus L. which is able to reduce DPPH free radicals. Method: Amaranthus hybridus L. were extracted with methanol solvent by maceration method in a ratio (1:10). Then a qualitative analysis was carried out in the form of phytochemical screening, identification of phenolic compounds by Thin Layer Chromatography (TLC) method using the methanol mobile phase: chloroform: n-hexane (1:9:1 v/v/v) and the stationary phase of silica gel GF254. Quantitative analysis of the total phenolic content test, and free radical suppression activity test by DPPH method which was measured using a UV-Vis spectrophotometer to calculate IC50. Result: Methanol extract of Amaranthus hybridus L. positively contains alkaloid compounds, phenolics, flavonoids, saponins, and tannins. The TLC Rf quercetin value is 0.475, and the Rf extract is two spots namely 0.35 and 0.837. Total phenolic content of 1.150 ± 0.025% and a free radical suppression activity of IC50 value of 14.786 ppm. Conclusion: Methanol extract of Amaranthus hybridus L. could be categorized as very strong.
Co-Authors Budi Rahayu, Budi Mafa , Sutri Hud Nurhasanah, Devika Sari, Kurnia Rahayu Purnomo