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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Sehat Mandiri Journal of Pharmaceutical and Sciences.
Balapadang, Rachel Noveriachristie
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Formulation and Evaluation of Transdermal Dissolving Microneedle Loaded with Ethanol Extract of Cocor Bebek Leaves (Kalanchoe pinnata) Balapadang, Rachel Noveriachristie; Sarie, Aldila Divana; Rosyidah, Safira; Zulqifli, Iqbal; Akifah, Muthia Nur; Zahra, Aliya Azkia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.378-385

Abstract

Background: Acne is a chronic skin inflammation caused by blockage of the sebaceous glands in the skin and hypercolonization of the acne-causing bacteria Propionibacterium acnes. Cocor bebek leaves (Kalanchoe pinnata) are known to contain various secondary metabolites, including flavonoids, with antibacterial activity. Objective: In an effort to prevent side effects from using oral and topical antibiotics to treat acne, an alternative acne treatment that is safer and more effective with a strong drug delivery system is needed: microneedle patch technology containing natural ingredients. Methods: A microneedle patch formulation of Cocor bebek leaf extract was developed using a combination of HPMC and PVP polymers. The evaluation of microneedle patches included irritation tests with rat test animals and antibacterial activity tests against Propionibacterium acnes. The results showed the formation of yellow microneedle patches with uniform needles. The evaluation results showed that the microneedle patch has an irritation index value classified as non-irritant and has antibacterial activity against Propionibacterium acnes, with the highest inhibitory diameter at an extract concentration of 30% with a moderate inhibition category. Conclusion: The microneedle patch cocor bebek leaf extract shows potential as an effective drug delivery system for the treatment of acne that is safe for use on the skin.
Efektivitas Produk Herbal Antijamur untuk Terapi Ketombe (Pityarisis capitis): Literature Review dan Analisis Bibliometrik Syahrin, Esti; Sudarjat, Hadi; Balapadang, Rachel Noveriachristie
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1802

Abstract

Dandruff (Pityriasis capitis) is a skin health problem caused by fungal growth on the scalp, increased production of oil glands (sebum) excessively. Current advances in science and technology have led to the development of herbal plant research to be used as antifungal herbal products in overcoming dandruff. The purpose of this literature review is to review and summarize herbal plants that have the potential to inhibit the growth of fungi that cause dandruff, so that it is useful to be developed as further research. Article searches were conducted from February to May 2024 using the Publish or Perish reference manager (PoP) tool in the Google scholar database source which was then term mapped in the Vosviewer software. The results of original research journal publications related to dandruff published in the range of 2014 to 2024 were obtained as many as 12 journals. The conclusion obtained in this literature review is that secondary metabolite compounds contained in herbal plants have a potential fungal inhibition mechanism, so it is appropriate to be developed in future research and used as an antifungal herbal product to treat dandruff.
Potensi Beta-Hydroxybutyrate (BHB) dalam Penanganan Diabetes Tipe 2 dan Risiko Ketoasidosis pada Pasien Diabetes Balapadang, Rachel Noveriachristie; Sudarjat, Hadi
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.520

Abstract

Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence every year, especially type 2 DM. Before insulin as a DM therapy, the ketogenic diet was known as the main nonpharmacological therapy, which is a high-fat, adequate-protein, and low-carbohydrate intake diet. A ketogenic diet causes the ketogenesis process and produces ketone bodies, one of which is beta-hydroxybutyrate (BHB) which has various therapeutic effects such as lowering blood sugar levels. This study is a narrative review compiled by searching the literature on Google Scholar and PubMed databases with keywords related to the research topic. Bibliometric analysis was also carried out with VOSviewer software to determine the keywords relevant to the research topic. The results of the reviews that have been carried out show that BHB has the potential as a therapeutic agent in patients with DM2 with various mechanisms of action in lowering blood sugar levels including increased insulin secretion, suppression of lipolysis, and decreased Ala release. BHB as a supplement has been widely studied for its therapeutic effects but it is necessary to pay attention to the side effects that can occur such as ketoacidosis.
Co-Authors Akifah, Muthia Nur Rosyidah, Safira Sarie, Aldila Divana Sudarjat, Hadi Syahrin, Esti Zahra, Aliya Azkia Zulqifli, Iqbal