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Normi, Normi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Other

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EDUKASI PENTINGNYA MENABUNG SEJAK DINI BAGI ANAK-ANAK DI DESA KOMPANG KABUPATEN SINJAI Ni'mah, Siar; Normi, Normi
Jurnal Graha Pengabdian Vol 6, No 1 (2024): MARET
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um078v6i12024p%p

Abstract

Saving is basically setting aside some of today's income to anticipate future needs, both unforeseen and unforeseen. It is very important to teach children and youth the importance of saving from an early age so that they are wiser in spending the money. The purpose of carrying out this activity is to teach children and youth the importance of saving from an early age so that they are wiser in spending the money. In time, they will buy the things they need and when there are things they want they don't have to worry about where they got the money to buy those things. The method used in carrying out this activity is the socialization of activities, giving material about the importance of saving, and the practice of making savings. The result of this educational activity is to make this activity a platform that provides hands-on experience to children and produces work in the form of savings, they are also more able to start managing their personal finances by setting aside some of their pocket money and making their provisions until adulthood. It is hoped that this activity will continue so that children can always get the latest inspiration.
In Silico Assessment of Chemical Constituents of Zingiber officinale Rosc. For Anti-diabetic Activity: Molecular Docking with α-Glucosidase Receptor Normi, Normi; Supandi, Supandi; Komala, Ismiarni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.36161

Abstract

Diabetes Mellitus (DM) is a disease in which blood sugar (glucose) levels are elevated because the body cannot release or utilize insulin adequately. Rhizome of Zingiber officinale Rosc. (ginger) has been reported to possess anti-diabetic properties. This study aimed to provide information on the chemical components of ginger that have potential in silico antidiabetic activity against the α-glucosidase receptor. Twenty chemical components of ginger (quercetin, catechin, humulene, β-sesquiphellandrene, camphene, farnesene, β-sitosterol, stigmasterol, curcumin, 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 8-shogaol, 10-shogaol, 6-paradol, 8-paradol, 10-paradol, methyl-6-gingerol, and methyl-8-gingerol) were used as ligands. An in silico study was conducted using the molecular docking technique with the AutoDock Vina software, which was then displayed using PyMOL and Biovia Discovery Studio. The grid box settings obtained in this study were as follows: center_x = -20.209, center_y = -6.763, center_z = 9.393, size_x = 12, size_y = 10, size_z = 12, and spacing (angstrom) = 1. The results indicated that the native ligand acarbose exhibited a binding energy of -6.9 kcal/mol. In contrast, four test ligands, quercetin (-7.3 kcal/mol), catechin (-7.1 kcal/mol), curcumin (-7.0 kcal/mol), and 6-gingerol (-7.0 kcal/mol) - demonstrated lower binding energies than acarbose, suggesting more stable conformations and more potent pharmacological effects. Lipinski analysis revealed that these four test ligands met all five Lipinski rule criteria. The study calculated the Root Mean Square Deviation (RMSD) value for the Docking of acarbose with the α-glucosidase macromolecule, resulting in a value of 0.384 Å. Interaction analysis conducted using Biovia Discovery Studio software revealed various interaction types, including hydrogen bonding, hydrophobic, electrostatic, and unfavorable interactions. In conclusion, this study provides valuable insights into potential therapeutic compounds derived from ginger and offers a foundation for further research and development in pharmaceutical and medicinal chemistry.
Co-Authors Komala, Ismiarni Ni'mah, Siar Supandi