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All Journal The International Journal of Medical Science and Health Research
Pramuliansyah Haq
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Effectiveness, Safety and Outcome of Low Dose Aspirin for The Prevention of Superimposed Preeclampsia in Women with Chronic Hypertension : A Comprehensive Systematic Review Andi Muh. Ariansyah Nazaruddin; Pramuliansyah Haq
The International Journal of Medical Science and Health Research Vol. 7 No. 3 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/paf1kr63

Abstract

Background: Low-dose aspirin therapy has been shown to reduce pregnancy-related complications, including pre-eclampsia, in pregnant women with chronic hypertension. However, mixed findings suggest that it does not significantly alter the likelihood of developing superimposed pre-eclampsia, preterm birth, or perinatal mortality in women with chronic hypertension. Methods: This systematic review complied with the PRISMA 2020 requirements, concentrating solely on full-text papers published in English from 2014 to 2024. Editorials and review articles lacking a DOI were omitted to guarantee the use of high-quality sources. A comprehensive literature review was performed using esteemed databases such as ScienceDirect, PubMed, and SagePub to locate pertinent studies. Result: The initial database search identified over 200 publications relevant to the topic. Following a meticulous three-stage screening process, eight studies were selected that met the predefined inclusion criteria for comprehensive analysis. These studies were subjected to a rigorous critical evaluation, providing an in-depth investigation into the effectiveness, safety, and outcomes of low-dose aspirin for the prevention of superimposed pre-eclampsia. This focused approach ensured that the analysis drew from high-quality evidence directly aligned with the study's objectives. Conclusion: Superimposed preeclampsia, a condition causing preterm birth and neonatal intensive care unit admissions, is a risk for chronic hypertension women. Aspirin, a low-dose medication, has shown mixed efficacy in preventing this condition, with dose-dependent effectiveness.
Association Between Cardio-Ankle Vascular Index and Early Detection of Heart Failure with Preserved Ejection Fraction: A Meta-Analysis Pramuliansyah Haq; Andi Muhammad Ariansyah N
The International Journal of Medical Science and Health Research Vol. 37 No. 2 (2026): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/vg1x7670

Abstract

Introduction: Heart failure with preserved ejection fraction (HFpEF) represents a growing clinical challenge with limited diagnostic tools for early detection. The Cardio-Ankle Vascular Index (CAVI) is a novel non-invasive measure of arterial stiffness that may facilitate early identification of HFpEF. Methods: This meta-analysis systematically reviewed 48 sources examining the association between CAVI and HFpEF. Studies were included if they assessed adult populations, measured CAVI, and reported quantitative associations with HFpEF or its surrogates. Data extraction focused on study design, CAVI measurement protocols, HFpEF definitions, and association measures. Results: Cross-sectional analyses demonstrated significant correlations between CAVI and diastolic function parameters: E/A ratio (r = -0.405, 95% CI -0.324 to -0.481) and e' velocity (r = -0.449, 95% CI -0.340 to -0.630) (1). CAVI ≥10 was associated with HFpEF hospitalization (OR 9.76) (6). Meta-analyses showed CAVI predicted cardiovascular events (HR 1.20-1.46 per SD/category increase) (8-10). Longitudinal data demonstrated CAVI progression correlated with left ventricular global longitudinal strain deterioration over 26.8 months (5). Sex-specific analysis revealed stronger associations in women (OR 1.67, P=0.007) (3). Discussion: CAVI demonstrates consistent associations with subclinical diastolic dysfunction and HFpEF outcomes. The evidence supports mechanistic plausibility through ventricular-vascular coupling, with distinct patterns in hypertensive and female subpopulations. However, significant limitations include predominance of Asian populations, absence of prospective screening studies, and lack of validated early detection thresholds. Conclusion: CAVI shows promise as a screening tool for early HFpEF detection, particularly in high-risk populations. Future research requires prospective studies with standardized protocols, population-specific thresholds, and evaluation of CAVI-guided intervention strategies.
Co-Authors Andi Muh. Ariansyah Nazaruddin Andi Muhammad Ariansyah N