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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan
Nurfiyana, Wahyu
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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T Allele of FOXO3 rs2802292 Increases CCL2 Concentration and Slightly Decreases TGF-β Concentration in Indonesian Elderly Nurfiyana, Wahyu; Iswanti, Febriana Catur; Hardiany, Novi Silvia
Molecular and Cellular Biomedical Sciences Vol 8, No 3 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i3.484

Abstract

Background: Cellular senescence and the senescence-associated secretory phenotype (SASP) are pivotal factors influencing aging and age-related diseases. SASP secretes cytokines, chemokines, metalloproteinases, and growth factors that cause chronic inflammation. C-C ligand 2 (CCL2) and transforming growth factor-beta (TGF-β) are SASP markers secreted by senescent cells. This study investigated the relationship between the FOXO3 variant rs2802292 and SASP markers, focusing on CCL2 and TGF-β.Materials and methods: A cross-sectional study involving 72 elderly individuals from Jakarta was conducted. A sandwich enzyme-linked immunosorbent assay (ELISA)was used to quantify CCL2 and TGF-β concentrations. Random blood glucose, blood pressure, and FOXO3 rs2802292 genotyping data were obtained from a previous study. Differences in CCL2 and TGF-β concentrations between genotype groups were analyzed using one-way ANOVA and the Kruskal-Wallis test. Meanwhile, differences in CCL2 and TGF-β concentrations between allele groups were analyzed using the Mann-Whitney test.Results: The CCL2 and TGF-β concentrations of the subjects were 66.5 (10.58-190.9) pg/mL and 6,319 (2,379-13,846) pg/mL, respectively. There were significant differences in CCL2 concentrations among the FOXO3 rs2802292 genotypes (p=0.041). However, there were no significant differences in TGF-β concentrations among FOXO3 rs2802292 genotypes (p=0.955). Subjects with the G allele had significantly lower CCL2 concentrations compared with those with the T allele (p=0.033). TGF-β concentrations did not significantly differ between G and T alleles (p=0.771).Conclusion: CCL2 concentrations are associated with the FOXO3 variant rs2802292 in the elderly population. The T allele of FOXO3 rs2802292 increased CCL2 concentration and slightly decreased TGF-β concentration in elderly individuals.Keywords: aging, SASP, CCL2, TGF-β, SNP, FOXO3, rs2802292
Analysis of the Relationship between Neutrophil-Lymphocyte Ratio (NLR) Values and Body Mass Index in Tuberculosis Patients Nurfiyana, Wahyu; Amien, A. Zakaria
Jurnal Kesehatan Vol 17 No 1 (2026): Jurnal Kesehatan (In Progress)
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v17i1.5529

Abstract

Tuberculosis (TB) is a communicable infectious disease that remains a major public health problem, particularly in Indonesia. Low nutritional status can impair immune function and worsen the clinical course of TB. Body Mass Index (BMI) is commonly used to measure nutritional status. In contrast, the neutrophil–lymphocyte ratio (NLR) is a simple inflammatory biomarker reflecting the balance between innate and adaptive immune responses. This study aimed to analyze the relationship between NLR and BMI among TB patients undergoing treatment. This cross-sectional study involved 32 tuberculosis patients receiving treatment at Puskesmas Sukabumi, Bandar Lampung. NLR values were obtained from blood tests using a hematology analyzer and calculated as the neutrophil count divided by the lymphocyte count. BMI was determined from body weight and height measurements. Statistical analysis included Spearman's correlation test to examine the relationship between NLR and BMI, and a One-Way ANOVA to assess differences in NLR across BMI classifications. The results showed that the mean BMI was 20.4±3.0 kg/m², and the median NLR was 2.7. A significant negative correlation was found between BMI and NLR (r = -0.379; p = 0.03), indicating that lower BMI was associated with higher NLR. Significant differences in NLR were also observed among BMI categories (p = 0.003), with underweight subjects demonstrating the highest NLR values. These findings suggest a relationship between nutritional status and systemic inflammatory responses in TB patients. BMI and NLR may serve as simple indicators for assessing inflammatory status and monitoring treatment progress in tuberculosis patients. 
Co-Authors Amien, A. Zakaria Febriana Catur Iswanti Novi Silvia Hardiany