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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia
Nugrahaningtyas, Odilia Danti
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Computer Science & IT Medicine & Pharmacology

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A Case Report: Risperidone-Induced Lactation Nonpuerperal in Bipolar Patient Rahajeng, Bangunawati; Maziyyah, Nurul; Nugrahaningtyas, Odilia Danti
Indonesian Journal of Clinical Pharmacy Vol 12, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.1.60

Abstract

Risperidone is an atypical antipsychotic for acute and chronic schizophrenia and mania. In this case report, we report a rare side effect of risperidone, namely nonpuerperal lactation, where the common side effects of risperidone are insomnia, anxiety, headaches, and extrapyramidal symptoms. Lactation nonpuerperal is one of the rare side effects of risperidone, with an incidence in adults < 1%. We report the case of a 21-year-old woman. This woman was diagnosed with bipolar affective disorder with major depression and got risperidone, fluoxetine, trihexyphenidyl, and valproic acid for treatment. The first visit was at a teaching hospital on April 21, 2022. She had to control it within a month. At the first control on July 1, 2022, her condition improved. She had no complaints. On August 4, 2022, she came to the hospital and told the doctor that she had nonpuerperal lactation. We do a causality analysis that the side-effect is due to risperidone. From Naranjo’s analysis, we scored 6 for risperidone (probable). From the Liverpool algorithm, we concluded that risperidone probably caused lactation nonpuerperal. In this case, risperidone probably caused lactation nonpuerperal.
Antipsychotic Side Effects Identification Using the Naranjo Algorithm at Hospital X Yogyakarta Nugrahaningtyas, Odilia Danti; Rahajeng, Bangunawati
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57955

Abstract

The escalating utilization of antipsychotics undeniably contributes to the heightened risk of drug side effects. This study aims to identify antipsychotic side effects and their causality. This study belongs to observational research with a descriptive cross-sectional design. The participants were patients prescribed antipsychotic drugs at Hospital X Yogyakarta between April and July 2022 who met the specified inclusion criteria. This study utilized accidental sampling, generating 61 patients as the participants. Data collection was carried out prospectively through interviews and medical records. The Naranjo algorithm was used to analyze causality. The predominant drug type administered to patients was atypical antipsychotics, with a total of 72 prescriptions. Risperidone accounted for the highest number of prescriptions, totaling 37 (22.16%). Weight gain contributed to the highest percentage of reported side effects, with 16 (16.33%) instances. The side effects with the highest causality score of 7 (probable) were breast secretion, tremors, palpitations, weight gain, and decreased blood pressure. Weight gain was the most frequently observed side effect when taken together. The maximum score for the causality association of side effects was an average of 7, indicating a probable connection. This study provides insight into the numerous side effects associated with prescription antipsychotic drugs.
Co-Authors Nurul Maziyyah Rahajeng, Bangunawati