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Pratama, Erdilian
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The impact of administering vitamin D supplements on handgrip strength and performance in the timed-up-and-go test in frail elderly individuals: A meta-analysis involving randomized controlled trials Pratama, Erdilian; Rizqiansyah , Chrisandi; Firmansah , Wahyu; Soenarti , Sri
Deka in Medicine Vol. 1 No. 1 (2024): April 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.v1i1.3

Abstract

BACKGROUND: Ongoing debates continue regarding the specific effects of vitamin D intake on the timed-up-and-go test and handgrip strength. OBJECTIVES: To assess the impact of vitamin D supplementation on handgrip strength and performance in the timed-up-and-go test. METHODS: Between May and June of 2023, a systematic review and meta-analysis were undertaken to assess the effects of vitamin D intake on handgrip strength and performance in the timed-up-and-go test. A comprehensive search was performed on Google Scholar, Web of Science, and PubMed to search for relevant articles published until June 2023. The analysis exclusively incorporated randomized controlled trials (RCTs) available in English publications, with a specific emphasis on evaluating the impact of vitamin D supplementation on both handgrip strength and performance in the timed-up-and-go test. Inverse variant meta-analysis was employed to evaluate the impact of vitamin D intake on the timed-up-and-go test and handgrip strength. RESULTS: A total of 21 appropriate studies were incorporated into the systematic review. Our findings revealed a favorable impact of vitamin D administration on enhancing performance in the timed-up-and-go test. Conversely, we could not ascertain any advantageous effects of vitamin D intake on handgrip strength. Despite the notable enhancement observed in the timed-up-and-go test, our analysis did not yield statistically significant evidence supporting the impact of vitamin D intake on handgrip strength based on the included studies. CONCLUSION: Our study findings reveal that vitamin D is an essential component in improving the timed-up-and-go test.
Acute liver failure caused by paracetamol intoxication in a severely depressed patient with suicidal intent: A case report Pratama, Erdilian; Rosandy, Milanitalia
Deka in Medicine Vol. 1 No. 3 (2024): December 2024
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2024.e470

Abstract

BACKGROUND: Paracetamol poisoning has extensive implications, and one of the most dangerous is the involvement of liver dysfunction. Such cases are rare but require comprehensive evaluation and management. CASE: A 19-year-old female presented to the Emergency Department (ED) with nausea, vomiting, and epigastric pain after ingesting 20 grams of paracetamol with alcohol in a suicide attempt. Her history revealed severe depression with symptoms of anhedonia, anergy, and self-harming behavior. Laboratory results showed elevated liver enzymes and prolonged coagulation time, though other organ functions were normal. She was diagnosed with acute liver failure due to paracetamol intoxication and was treated with N-acetylcysteine (NAC), omeprazole, ondansetron, vitamin K, and psychiatric counseling. After seven days of hospitalization, her clinical condition improved, with plans for outpatient follow-up and prescribed medications. CONCLUSION: This case highlights the importance of addressing adolescent mental health and providing education on the dangers of drug overdose, along with access to psychological support to prevent self-harm.
Co-Authors Firmansah , Wahyu Rizqiansyah , Chrisandi Rosandy, Milanitalia Soenarti , Sri