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All Journal Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) Academic Hospital Journal
Molidia, Sri Rahmat
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Comparison of Clinical Outcomes Between Acetylcysteine and Ambroxol in Post Acute Exacerbation of COPD Patients Molidia, Sri Rahmat; Pramantara, Dewa Putu; Ikawati, Zullies
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.58-66.2024

Abstract

Literature studies show that the use of acetylcysteine or ambroxol can accelerate improvement of clinical outcomes of post acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients. This study aims to compare the clinical outcomes of acetylcysteine and ambroxol administration in post AECOPD patients. The study was cohort design, prospective, to comparison of clinical outcomes of acetylcysteine and ambroxol with post AECOPD outpatients coming for clinical chekups in August 2023 at Respira Lung Hospital Yogyakarta. Clinical outcomes parameters were observed on day zero and thirty for CAT score and day zero and four for cough score. The patients were categorized into two groups: acetylcysteine group (n=30) and ambroxol group (n=30). There was no significant difference between two groups to change of CAT score and cough score (p>0.05) post AECOPD. The acetylcysteine group compared to ambroxol, there was a mean decrease in morning cough score -1.10±1.11 vs -0.87±1.12 (p=0.228), night cough score -1.53±1.43 vs -1.13±1.31 (p=0.438), and CAT score -2.43±5.45 vs -2.90±3.41 (p=0.391). Providing additional therapy of acetylcysteine or ambroxol in this study did not significantly reduce cough scores and CAT scores in post AECOPD patients.
Kajian Literatur: Efektivitas Asetilsistein Dosis Tinggi Pada Pasien PPOK Molidia, Sri Rahmat; Pramantara, Dewa Putu; Ikawati, Zullies
Majalah Farmaseutik Vol 21, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i3.93852

Abstract

Penyakit paru obstruktif kronik (PPOK) merupakan penyebab utama mortalitas dan morbiditas di seluruh dunia, ditandai dengan keterbatasan aliran udara yang persisten, hipersekresi mukus, stres oksidatif, dan inflamasi saluran napas. Asetilsistein memiliki sifat antioksidan dan antiinflamasi, yang telah menunjukkan manfaat bergantung pada dosisnya. Review ini menilai efektivitas dosis tinggi dari asetilsisitein pada pasien PPOK dalam memperbaiki luaran klinis dan frekuensi eksaserbasi. Studi Randomized Control Trial (RCT) dilibatkan dalam kajian literatur ini mengikuti daftar checklist PRISMA. Hasil review dari 6 RCT menunjukkan bahwa pemberian asetilsistein dosis tinggi (>400 mg perhari) secara signifikan dapat menurunkan frekuensi eksaserbasi, memperbaiki fungsi paru (FEV1, FVC, FEV/FVC), perubahan biomarker oksidasi dan inflamasi (Malondialdehid, Glutation, Glutation Peroksida, Cystein, C-Reactive protein). Kesimpulan dari penambahan terapi asetilsistein dosis tinggi mampu menurunkan frekuensi eksaserbasi dan perbaikan klinis secara signifikan dibandingkan plasebo
Impact of Pharmacist Counseling Strategy On Adherence And Knowledge of Chronic Kidney Disease Patients: Quasi-Experimental Assessment Filliana, Ulfa -; Oktasari, Sholikhah Rosvita; Molidia, Sri Rahmat; Yasin, Nanang Munif; Kristina, Susi Ari
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.110980

Abstract

Background: Chronic kidney disease is a progressive condition that requires proper management to slow the decline in kidney function and reduce the risk of complications. Patients with low adherence have an increased risk of kidney progression, and knowledge level plays an important role in the treatment of kidney patients and in collaborative treatment decision-making. This study aims to evaluate the impact of a pharmacist counselling strategy on adherence and knowledge levels in CKD patients.Method: The method was quasi-experimental, with a pretest-posttest design, comparing the intervention and control groups. The intervention was carried out once a week for 1 month, using leaflets as a tool, with inclusion and exclusion criteria, among chronic kidney disease patients during September-October 2023.Result:  The study included 57 patients: 29 in the control group and 28 in the intervention group. The result showed that in the intervention group, there was an increase in knowledge, with a difference between pretest and posttest scores of Δ 8.79±7.802, compared to the control group, which showed a decrease in scores of Δ -0,49±4,932 (p=0.000). Adherence in the intervention group increased by Δ 2,71±1,822 compared to the control group, while adherence in the control group decreased by Δ -0,44±1,152 (p=0.000). A contributing factor to the patient's level of knowledge and compliance was duration of hemodialysis, p=0.032.Conclusion: The conclusion was that the pharmacist counselling strategy significantly improved CKD patient knowledge and medication adherence, and that the duration of hemodialysis significantly contributed to CKD patients' knowledge.
Comparison of The Effectiveness of Intermittent and Continuous Pantoprazole Therapy in Peptic Ulcer Disease Bleeding Wirastuti, Ade; Molidia, Sri Rahmat; Salsabela, Salsabela; Anisya, Kharina; Deisberanda, Fortunata Saesarria; Aqsa, Kathina Deswi; Ajwad, Muhammad Nur; Dermawan, Abdurraafi' Maududi; Fakhruddin, Fakhruddin; Rommy, Rommy
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.115539

Abstract

Background:  Peptic ulcer disease with melena is commonly encountered in clinical practice. Pantoprazole is widely used to control bleeding and heal ulcers, but there is still debate regarding the effectiveness of intermittent bolus administration compared to continuous infusion.Objective: To review and evaluate the literature on the comparative effectiveness of pantoprazole administered via intermittent bolus versus continuous infusion.Methods: This study employed a narrative literature review design. Literature searches were conducted in the PubMed, Google Scholar, ProQuest, and Sage Journals databases for publications from 2020 to 2025 using the keywords: “pantoprazole,” “continuous infusion,” “intermittent bolus,” “effectiveness,” “bleeding,” and “peptic ulcer disease”.Result: Four articles met the inclusion criteria. Two studies reported no significant difference between intermittent bolus and continuous infusion administration. One study found that intermittent bolus administration was associated with a shorter length of stay, whereas another recommended continuous infusion for patients at high risk of upper gastrointestinal bleeding. There was heterogeneity in study design and reported outcomes.Conclusion: There is no significant difference between continuous infusion and intermittent bolus administration of pantoprazole; given the limited number and quality of studies, further research is needed.
Co-Authors Ade Wirastuti, Ade Ajwad, Muhammad Nur Anisya, Kharina Aqsa, Kathina Deswi Deisberanda, Fortunata Saesarria Dermawan, Abdurraafi Maududi Fakhruddin Fakhruddin Filliana, Ulfa - Nanang Munif Yasin Oktasari, Sholikhah Rosvita Pramantara, Dewa Putu Rommy, Rommy Salsabela, Salsabela Susi Ari Kristina