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All Journal Indonesian Journal of Biotechnology Jurnal Ilmu Kefarmasian Indonesia
Tan, Santi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Hand, foot, and mouth disease in children: forecasting of future research direction using bibliometric analysis Tan, Santi; Tjandrawinata, Raymond Rubianto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1563

Abstract

Since 1997, hand, foot, and mouth disease (HFMD) has become a common health problem in Southeast Asia. Various types of research have been conducted and published to handle HFMD. However, until now, many children, especially in the Asia-Pacific region, including Indonesia, still have HFMD-causing enterovirus (EV) infection. By conducting a bibliometric analysis of the literature published over the last 27 years (1997–2024), the direction of HFMD research in children can be predicted, thus research areas that have the potential and still need to be developed for future better HFMD treatment can be known. The important HFMD research topics predicted to continue to develop were identified through keyword analysis, which was subsequently mapped using a network approach. Based on this study, it can be concluded that HFMD research is predicted to lead to the development of synbiotic supplements, which can reduce HFMD severity, especially in children, by utilizing a genome-wide association study (GWAS) and machine learning.
Network pharmacology‐based exploration of gut microbiota‐derived metabolites for type‐2 diabetes Widjaja, Nadia; Simatupang, Stefeny Theresia; Tan, Santi; Tjandrawinata, Raymond Rubianto
Indonesian Journal of Biotechnology Vol 30, No 3 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.107382

Abstract

Probiotics confer health benefits and have been investigated for their potential therapeutic properties in type‐2 diabetes (T2D) treatment. This study employs a network pharmacology approach to explore gut microbiota‐derived metabolites that potentially alleviate T2D. Several strains and species of gut microbiota were identified that may produce metabolites with therapeutic potential for T2D. Interestingly, quercetin produced by Bacteroides uniformis and daidzein produced by Bifidobacterium adolescentis and Bifidobacterium breve have been studied for their antidiabetic effects. Using a network pharmacology approach, it was found that quercetin may target AKT1 and EGFR, critical proteins involved in insulin signaling pathways related to T2D. Additionally, 10‐oxo‐11‐octadecenoic acid produced by Lactobacillus plantarum and 10‐keto‐12Z‐octadecenoic acid produced by Lactobacillus paracasei were found to target PPARG, a gene regulating insulin signaling. These findings were further validated by the molecular docking analysis, which showed suitable to satisfactory binding strengths.
Co-Authors Raymond R. Tjandrawinata Simatupang, Stefeny Theresia Widjaja, Nadia