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All Journal Indonesian Journal of Medicine Journal Orthopaedi and Traumatology Surabaya (JOINTS)
Ustriyana, Nyoman Gede Grenata Nanda
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Health Professions Medicine & Pharmacology Public Health

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The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review Aryana, I Gusti Ngurah Wien; Febyan, Febyan; Ustriyana, Nyoman Gede Grenata Nanda
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i2.2024.84-99

Abstract

Background: Articular cartilage injuries often result from trauma, genetic predisposition, and degeneration. These injuries lack inherent regeneration mechanisms due to the absence of blood vessels and limited progenitor cell entry. Osteoarthritis is characterized by gradual cartilage deterioration. Mesenchymal stem cells (MSCs), particularly their secretome including exosomes, hold promise as a regenerative therapy. This review explores the application of MSCs and their secretome to address cartilage defects.Methods: This review was conducted based on PRISMA guidelines. Animal model studies focusing on the use of stem cell secretomes for cartilage regeneration were explored. The search, encompassing PubMed, MEDLINE, the Cochrane Library, Scopus, Web of Science, and Science Direct from January 10, 2023, to July 27, 2023, was conducted utilizing Google Chrome as the search engine. Studies with outcomes based on OARSI or ICRS scores, as well as any additional outcomes related to MSC secretome utilization, cartilage regeneration, and proliferation, were included.Results: Our systematic review identified six studies using MSCs in vivo and in vitro. Synovial membrane-derived MSCs significantly enhanced cartilage regeneration by elevating chondrogenic capabilities. Hydrogel-based systems techniques and 3D-printed scaffolds have emerged for innovative delivery. Specific microRNAs, such as miR-92a-3p, have been recognized for enhancing cartilage regeneration. Strategies for the effective targeting of MSC exosomes to the precise cartilage damage site have been explored.Conclusions: The studies demonstrate the potential of MSC-derived secretomes and exosomes for knee cartilage regeneration in animal models. Further research and clinical trials are needed to refine these approaches for practical application.
Surgical Precision in Lumbar Spinal Canal Stenosis: Optimizing Outcomes in a Young Adult with Suspected Infection through Decompression-Stabilization-Fusion Putra, I Gusti Ngurah Paramartha Wijaya; Febyan; Ustriyana, Nyoman Gede Grenata Nanda
Indonesian Journal of Medicine Vol. 9 No. 2 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.2.747

Abstract

Background: This case report examines the uncommon occurrence of Lumbar Spinal Canal Stenosis (LSCS) in a 23-year-old male patient, highlighting the diagnostic challenges and unique aspects of managing this condition in young adults. Typically associated with aging and degenerative changes, LSCS poses a diagnostic dilemma when encountered in a young individual with nonspecific causation. Case Presentation: The patient reported persistent lower back pain since February 2023, primarily on the right side, escalating over the past three months. The pain intensified during prolonged sitting, standing, and walking, alleviated by lying down and analgesics. Radiating pain to both buttocks and legs, particularly on the right side, accompanied a four-month history of persistent right foot numbness. Referred from RS Siloam Kupang to RSAD Denpasar and subsequently to RSUP Prof IGNG Ngoerah, the patient received a diagnosis of Lumbar Spinal Canal Stenosis at L2-L3-L4, L5-S1, with suspected Spondylitis TB. Results: This case underscores the intricacies of diagnosing Lumbar Spinal Canal Stenosis in young adults, emphasizing the exploration of non-traditional causes. The patient underwent Debridement-Decompression-Stabilization-Fusion-Biopsy+Culture, experiencing postoperative improvement. Cultures showed no growth, and biopsy results were nonspecific. The final diagnosis was Lumbar Spinal Canal Stenosis at L2-L3-L4, L5-S1 due to Spondylitis TB dd/Pyogenic Infection, with bilateral Neural Foraminal Stenosis Grade III at L5. The discussion focuses on the rarity of this presentation in young individuals, challenges in diagnosis, and the efficacy of decompression-stabilization-fusion treatment for achieving positive outcomes in young adult patients. Conclusion: The case discussion emphasizes the complexity of managing Lumbar Spinal Canal Stenosis in a young adult, particularly when infection is suspected. The decision to pursue Decompression-Stabilization-Fusion was rooted in the patient's age, the need for structural stability, and the suspicion of infection.
Co-Authors Aryana, I Gusti Ngurah Wien Febyan Febyan, Febyan Putra, I Gusti Ngurah Paramartha Wijaya