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All Journal Majalah Kedokteran Bandung Indonesian Journal of Cancer
Azhar, Raden Yohana
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation Between CA 15-3 And Miller Payne Histopathological Response In Locally Advanced Breast Cancer Undergoing FAC Regiment Neoadjuvant Chemotherapy Rizki, Kiki Akhmad; Azhar, Raden Yohana; Dewayani, Birgitta; Fahman, Aulia Novariza
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3145

Abstract

Response to chemotherapy for breast cancer can be assessed using the CA 15-3 tumor marker, or through histopathological means such as Miller Payne assessment. This study aimed to explore the correlation between CA 15-3 level and histopathological response in locally advanced breast cancer. This is a cross-sectional study measuring CA 15-3 before and after neoadjuvant chemotherapy using the FAC regiment. This study took place in Dr. Hasan Sadikin Hospital Bandung, Indonesia, from January to August 2022. Data on histopathological responses before chemotherapy and after surgery were also collected. Thirty-nine patients were admitted as subjects. Most patients had invasive carcinoma of no special type (79.5%) and luminal B HER 2 molecular subtype (38.5%). A significant decrease in CA 15-3 level after chemotherapy (from 23.54±18.38 ng/ml to 16.30±6.51 ng/mL) was observed. No significant correlation between CA 15-3 level and Miller Payne histopathological responses were found in the subjects.
Basal Cell Carcinoma Risk Factors: A Case-Control Study from Dr. Hasan Sadikin Hospital of Bandung, Indonesia Rulandani, Redi; Azhar, Raden Yohana; Putri, Almahitta Cintami
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1250

Abstract

Background: Basal Cell Carcinoma (BCC) is the most common non-melanoma skin cancer in humans (75%). BCC is a slow-growing, malignant tumor with a destructive nature, yet it rarely metastasizes. Prevention is better than curative medicine. The risk factors of BCC in Bandung area are still not known. Hence, a study regarding BCC risk factors in Bandung is needed. The objective in this paper is to determine basal cell carcinoma risk factors in Dr. Hasan Sadikin Hospital, Bandung, Indonesia.Method: Analytical research with a case-control approach was carried out on patients with a diagnosis of BCC who came to Dr. Hasan Sadikin Hospital outpatient clinic in Bandung between July and December 2023. Data was collected and analyzed with SPSS version 29.0 using the chi-square method to determine the association between risk factors and BCC occurrence. Risk factors studied in this research were age, gender, occupation, family history, Fitzpatrick skin phototype, duration of sun exposure, time of sun exposure, smoking, alcohol, and chemical exposure.Results: There were 41 subjects in the case group and 82 subjects in the control group. The results of bivariate analysis using chi-square showed that old age (p 0.001; OR (95% CI = 6.35 (2.51–16.04)), duration of sun exposure 8–40 hours within a week (p = 0.049; OR (95% CI) = 2.09 (0.98–4.49)), and sun exposure time from 06.00 to 18.00 (morning to evening) (p = 0.026; OR (95% CI) = 7.25 (2.07–25.41) had significant association with the occurrence of breast cancer. Conclusion: The study conducted at Dr. Hasan Sadikin Hospital, Bandung, found that significant risk factors associated with Basal Cell Carcinoma (BCC) are advanced age, sun exposure duration of 8 to 40 hours per week, and sun exposure during the hours of 06:00 to 18:00 (morning to evening). These findings emphasize the importance of preventive measures by limiting sun exposure, especially among the older population, to reduce the risk of BCC in the Bandung area.
Co-Authors Dewayani, Birgitta Fahman, Aulia Novariza Kiki Akhmad Rizki, Kiki Akhmad Putri, Almahitta Cintami Rulandani, Redi