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Chandra Sekhar Naik D
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Medicine & Pharmacology

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Development and in vitro evaluation of acelofenac mouth dissolving films for reduced analgesic activity Chandra Sekhar Naik D; Bharathi Arigela; Venkata Suresh Babu Agala; Cherukuri Vidyulatha Chowdary
Journal of Applied Pharmaceutical Research Vol. 12 No. 5 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i5.612

Abstract

Background: The design of the current research work was to formulate mouth-dissolving films (MDFs) of aceclofenac (ACF) to improve patient compliance and convenience for older and younger patients, ultimately leading to improved therapeutic outcomes. Method: Evaluations were conducted on film formers such as HPMC and MC and film modifiers such as PEG and starch acting as solubilizing agents. Results: The physicomechanical qualities, in vitro disintegration time, and in vitro dissolving characteristics of the produced MDFs were assessed. Good mechanical qualities, including as tensile strength, folding durability, and percentage elongation, were demonstrated by every created MDF. FTIR, SEM, and X-RD analyses were used to assess MDFs. In contrast to other formulations, MDFs containing F8 provided superior dissolving properties. Conclusion: When pitted against other mixtures, the MDFs with sodium alginate (5%), methylcellulose (5%), and hydroxypropyl methylcellulose (HPMC)(5%) showed superior dissolving capabilities. In contrast to other mixtures, the F8 mixture, including HPMC, sodium alginate, and methylcellulose, demonstrated a complete and accelerated dissolution within 50 seconds. The mechanism behind this release is diffusion, as indicated by the release kinetics data.
Formulation and evaluation of diclofenac emulgel using natural permeation enhancers Chandra Sekhar Naik D; Shaik Noor Mahammed; Mudigedu Samreen; S. Vamsi; P. Hemalatha
Journal of Applied Pharmaceutical Research Vol. 13 No. 2 (2025)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v13i2.907

Abstract

Background: This study aimed to formulate a stable diclofenac emulgel and determine the penetration rate using different natural penetration enhancers. Methodology: Carbopol (934) and Hydroxypropyl methyl cellulose (HPMC) were utilized as gelling agents due to their favorable viscosity characteristics, which render them widely used for regulating the flow properties of topically administered dosage forms. In the research, diclofenac served as the active ingredient, while Carbopol (934) & HPMC (0.5%) acted as gelling forms to form a proper gel base. Emulsion contains Tween-20 (0.05%), PEG (0.6%), liquid paraffin (0.75%), span-20 (0.1%), along with natural penetration enhancers (0.3%) initially prepared gel base & the emulsion with natural penetration enhancers combine conjointly to shape an appropriate diclofenac emulgel. Results and discussion: According to the study, the improved batch exhibits a 95.08% release in 48 hours and remains stable for about three. The optimized batch exhibits 46.6% suppression in the microbiological assay, whereas the marketed treatment only demonstrates 32.3% inhibition. However, the skin irritation test results have no erythema or edema. The rabbits' skin showed no signs of discomfort. According to stability experiments, the synthesized emulgel's antifungal activity, rheological analysis, in vitro drug release, and physical appearance did not alter after three months of storage. Conclusion: Overall, it was recommended that, in contrast to cream, the emulgel formulation come after the drug release for controlled, long-term drug delivery.
Co-Authors Bharathi Arigela Cherukuri Vidyulatha Chowdary Mudigedu Samreen P. Hemalatha S. Vamsi Shaik Noor Mahammed Venkata Suresh Babu Agala