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All Journal Journal of Multidisciplinary Applied Natural Science
Imtiyaz Olaf Jatmy
Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Bandung Institute of Technology, Bandung-40132 (Indonesia)
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics

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Residential Environment and Parental Lifestyle as Risk Factors of The Co-Occurrence of Cleft Lip and Palate Birth Defect Cases in Indonesia Katharina Oginawati; Intan Nur’azizah Rahman; Nurul Fahimah; Rinaldy Jose Nathanael; Imtiyaz Olaf Jatmy; Taqya Izdihar Muhanandi; Ida Latifah; Andi Tajrin; Ikeu Tanziha; Shinta Silvia; Farah Asnely Putri; Ida Ayu Astuti; Asri Arumsari; Utriweni Mukhaiyar
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.232

Abstract

Cleft lip and palate (CLP) are multifactorial birth defects, and the etiology behind their occurrence remains insufficiently understood. This case-control study aimed to investigate the association between residential environmental factors, parental lifestyle, and the risk of CLP in Indonesia. A total of 213 participants from 14 provinces were selected using stratified random sampling. Multivariable logistic regression was employed to determine the odds ratios (ORs) with 95% confidence intervals (CIs) for each risk factor. The study identified significant associations between several residential environmental factors and CLP. Proper kitchen ventilation was found to be protective (OR = 0.245, 95% CI: 0.096–0.624, p = 0.003), while proximity to industrial sites significantly increased the risk (OR = 3.595, 95% CI: 1.029–12.558, p = 0.045). Additionally, using treated drinking water showed a protective effect (OR = 0.39, 95% CI: 0.16–0.95, p = 0.038), whereas concerns about water sources displayed a marginally significant risk increase (OR = 2.841, 95% CI: 0.876–9.211, p = 0.082). Regarding parental lifestyle factors, maternal active smoking exhibited a marginal protective association (OR = 0.052, 95% CI: 0.002–1.09, p = 0.057), while paternal passive smoking presented a marginally significant risk (OR = 2.309, 95% CI: 0.897–5.942, p = 0.083). Furthermore, paternal radiation exposure was associated with an elevated risk of CLP (OR = 3.489, 95% CI: 0.828–14.703, p = 0.089). These findings highlight the need for targeted public health interventions to mitigate environmental exposures and promote safer parental lifestyle behaviors in Indonesia.
Co-Authors Andi Tajrin Asri Arumsari Farah Asnely Putri Ida Ayu Astuti Ida Latifah Ikeu Tanziha Intan Nur’azizah Rahman Katharina Oginawati Nurul Fahimah Rinaldy Jose Nathanael Shinta Silvia Taqya Izdihar Muhanandi Utriweni Mukhaiyar