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All Journal Journal of Pharmacopoeia Journal of Pharmacopoeia
Nahla Akila Fikria
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Sriwijaya, Indonesia
Medicine & Pharmacology Veterinary Other

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The Role of Traditional Medicines as Chemopreventive and Suppressive Agents in Cancer Treatment Deanova Insiratu Nurul Andini; Gilang Kurniawan; Nahla Akila Fikria
Journal of Pharmacopoeia Vol. 1 No. 1 (2024): MARET-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/yhfqm859

Abstract

The purpose of this study was to determine the role of traditional medicine as a chemopreventive and suppressive agent in the treatment of Deanova Insiratu Cancer. This study is a qualitative study, this study will use a retrospective and prospective observational approach. Data will be collected from the medical records of patients who have used Deanova Insiratu previously, as well as from direct observation and interviews with individuals who are currently using or have experience with this traditional medicine.  Research Results Cancer or malignant tumors can occur due to the growth of body tissue cells that proliferate abnormally. Cancer prevention can be done with healthy living habits and avoiding risk factors that can cause cancer. Cancer treatment can be done in 4 ways, namely by surgery, radiotherapy, immunotherapy and chemotherapy. Cancer screening can be done with mammography, ultrasonography (USG), and Magnetic Resonance Imaging (MRI). Natural ingredients that have effects as cancer prevention and help cancer treatment include Soursop leaves (Annona muricata), Celery leaves (Apium graveolans linn), Red Atai Spike leaves (Angiopteris ferox copel), Benalu Kepel (Dendrophthoe pentandra (L.) Miq.), and Tapak Dara leaves (Catharanthus roseus).
Biofarmasetics and Pharmacokinetics Study Analysis of Paracetamol Excretion Through Urine and Saliva Nahla Akila Fikria
Journal of Pharmacopoeia Vol. 1 No. 1 (2024): MARET-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/ct7faz89

Abstract

The purpose of this study was to determine that Paracetamol, also known as acetaminophen, is a commonly used analgesic and antipyretic drug to relieve pain and reduce fever. The process of metabolism and elimination of paracetamol from the body is important to understand, especially in the context of the safe use of this drug. This study aims to analyze the biopharmaceutics and pharmacokinetics studies of paracetamol excretion through urine and saliva as important indicators in understanding the metabolic and elimination processes of this drug. Paracetamol is rapidly and efficiently absorbed through the gastrointestinal tract, reaches the highest concentration in plasma in a short time, and is dispersed throughout the body fluids. The metabolic process of paracetamol mainly occurs in the liver, through two main phases: oxidation and conjugation with glucuronic and sulfuric acids.  Excretion of drugs and their metabolites can occur through urine and saliva, with the kidney as the main organ in the excretion process. Qualitative analytical methods were used in this study to identify paracetamol metabolite compounds in urine and saliva samples and to evaluate the metabolic pathways involved. Glucoronide, sulfate, and phenol conjugate assays were used to detect the presence of paracetamol metabolites in the samples. The assay results showed that urine was more effective in excreting paracetamol compared to saliva. In conclusion, this study provides a better understanding of the metabolic process and elimination of paracetamol from the human body through the analysis of biopharmaceutics and pharmacokinetics studies. These results are important for understanding the therapeutic effects and toxicity of paracetamol as well as for developing more effective and safe drug use management strategies.
The Role of Traditional Medicines as Chemopreventive and Suppressive Agents in Cancer Treatment Deanova Insiratu Nurul Andini; Gilang Kurniawan; Nahla Akila Fikria
Journal of Pharmacopoeia Vol. 1 No. 1 (2024): MARET-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/yhfqm859

Abstract

The purpose of this study was to determine the role of traditional medicine as a chemopreventive and suppressive agent in the treatment of Deanova Insiratu Cancer. This study is a qualitative study, this study will use a retrospective and prospective observational approach. Data will be collected from the medical records of patients who have used Deanova Insiratu previously, as well as from direct observation and interviews with individuals who are currently using or have experience with this traditional medicine.  Research Results Cancer or malignant tumors can occur due to the growth of body tissue cells that proliferate abnormally. Cancer prevention can be done with healthy living habits and avoiding risk factors that can cause cancer. Cancer treatment can be done in 4 ways, namely by surgery, radiotherapy, immunotherapy and chemotherapy. Cancer screening can be done with mammography, ultrasonography (USG), and Magnetic Resonance Imaging (MRI). Natural ingredients that have effects as cancer prevention and help cancer treatment include Soursop leaves (Annona muricata), Celery leaves (Apium graveolans linn), Red Atai Spike leaves (Angiopteris ferox copel), Benalu Kepel (Dendrophthoe pentandra (L.) Miq.), and Tapak Dara leaves (Catharanthus roseus).
Biofarmasetics and Pharmacokinetics Study Analysis of Paracetamol Excretion Through Urine and Saliva Nahla Akila Fikria
Journal of Pharmacopoeia Vol. 1 No. 1 (2024): MARET-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/ct7faz89

Abstract

The purpose of this study was to determine that Paracetamol, also known as acetaminophen, is a commonly used analgesic and antipyretic drug to relieve pain and reduce fever. The process of metabolism and elimination of paracetamol from the body is important to understand, especially in the context of the safe use of this drug. This study aims to analyze the biopharmaceutics and pharmacokinetics studies of paracetamol excretion through urine and saliva as important indicators in understanding the metabolic and elimination processes of this drug. Paracetamol is rapidly and efficiently absorbed through the gastrointestinal tract, reaches the highest concentration in plasma in a short time, and is dispersed throughout the body fluids. The metabolic process of paracetamol mainly occurs in the liver, through two main phases: oxidation and conjugation with glucuronic and sulfuric acids.  Excretion of drugs and their metabolites can occur through urine and saliva, with the kidney as the main organ in the excretion process. Qualitative analytical methods were used in this study to identify paracetamol metabolite compounds in urine and saliva samples and to evaluate the metabolic pathways involved. Glucoronide, sulfate, and phenol conjugate assays were used to detect the presence of paracetamol metabolites in the samples. The assay results showed that urine was more effective in excreting paracetamol compared to saliva. In conclusion, this study provides a better understanding of the metabolic process and elimination of paracetamol from the human body through the analysis of biopharmaceutics and pharmacokinetics studies. These results are important for understanding the therapeutic effects and toxicity of paracetamol as well as for developing more effective and safe drug use management strategies.
Co-Authors Gilang Kurniawan Nurul Andini