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All Journal SCRIPTA SCORE Scientific Medical Journal Journal of Health Management and Pharmacy Exploration (JOHMPE) Public Health Risk Assesment Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Meidina, Adinda Nezma
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The potential of ingestible sensors combined with family involvement interventions for medication supervision in Tuberculosis patients: A literature review Meidina, Adinda Nezma; Ramadhanti, Nafilah; Riza, M. Aidil Tarensyah; Dapala, Zelka; Fareza, M. Daffa
Public Health Risk Assesment Journal Vol. 2 No. 2: January (2025)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/phraj.v2i2.2025.1516

Abstract

Background: Tuberculosis (TB) is an airborne infectious disease that remains the second leading cause of death from infectious diseases globally. A major challenge in eliminating TB, despite it being preventable and curable, is the low adherence to treatment. This literature review aims to provide insights into the potential of ingestible sensors combined with family involvement interventions for medication supervision in TB patients, ensuring that medications are actually swallowed and addressing a key limitation of the previous DOT method. Methods: This study used a literature review method with the keywords "family engagement intervention", "digestible sensor", and "tuberculosis [MeSH]" to search databases such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion criteria included in vitro and in vivo experimental studies, cohort studies, comparative analysis studies, and reviews published in the last 10 years. Exclusion criteria included incomplete studies, inaccessible papers, and non-English/Indonesian texts. After applying these criteria, 35 journals and 1 book were selected for review and analysis. Findings: Ingestible sensors have shown over 80% effectiveness in monitoring medication adherence by providing real-time data for precise treatment adjustments. When combined with family involvement, these interventions address psychosocial barriers like stigma and lack of support, further improving adherence. This synergy significantly reduces non-compliance, prevents drug resistance, and enhances treatment outcomes for TB patients. Conclusion: Ingestible sensors combined with family involvement offer a more effective approach to TB treatment by ensuring medication is swallowed and providing psychosocial support, reducing risks of transmission, relapse, and drug resistance. However, equitable access and adequate infrastructure, supported by government and societal cooperation, are crucial for the successful implementation of this system globally. Novelty/Originality of this article: This study explores the innovative use of ingestible sensors combined with family involvement to improve TB treatment adherence, offering a novel contribution to TB management.
Effectiveness and safety of the monoclonal antibody drug lecanemab (Leqembi) in reducing beta-amyloid plaques in alzheimer's dementia: a literature review Meidina, Adinda Nezma; Ramadhanti, Nafilah; Istiqomah, Dyah Fatha; Putri, Yolanda Delia; Hasibuan, Nabila Az-zahra
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.547

Abstract

Dementia is a syndrome characterized by cognitive decline, behavioral changes, and impaired self-care, with Alzheimer's disease (AD) being the most common cause. The global prevalence of AD is rising and is expected to reach 152 million cases by mid-century, imposing significant public health and economic burdens, particularly in low- and middle-income countries. AD is marked by synapse loss and neuronal atrophy, beginning in the hippocampus and spreading across the cerebral cortex due to β-amyloid plaque and neurofibrillary tangle accumulation, which disrupt neuronal communication and survival. Current treatments, such as memantine and cholinesterase inhibitors, provide only temporary symptom relief without stopping disease progression. Literature was searched using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were applied, resulting in 27 relevant references that explored monoclonal antibody-based therapies and multidisciplinary interventions for AD management. Lecanemab has been shown to reduce amyloid accumulation effectively. However, its use is associated with risks such as amyloid-related imaging abnormalities with edema (ARIA-E) and hemorrhage ARIA-H, particularly in ApoE ε4 carriers. Despite these concerns, recent meta-analyses suggest that lecanemab is generally well-tolerated and offers potential as a cost-effective treatment for AD. Monoclonal antibody therapies, such as lecanemab, provide hope for slowing AD progression. Further research is crucial for developing more effective treatments. A multidisciplinary approach that integrates pharmacological therapies with advanced technologies may offer a more effective strategy for managing AD in the future.
Potensi Campuran Ekstrak Air Daun Salam (Syzygium polyanthum) dan Daun Sambiloto (Andrographis paniculata) sebagai Terapi Adjuvan dalam Tatalaksana Penyakit Diabetes Melitus Tipe 2 di Indonesia Meidina, Adinda Nezma; Ramadhanti, Nafilah; Triandra, Akbar; Putri, Yolanda Delia; Muftaridi, Rajwa Fairuz Putri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.772

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder that continues to increase in prevalence every year, especially in Indonesia. In molecular mechanisms, T2DM is closely related to oxidative stress and inflammation. This literature review is intended to further examine the potential of a mixture of aqueous extracts of S. polyanthum and A. paniculata leaves as an adjuvant therapy for T2DM in Indonesia. Methods: Literature was searched using Google Scholar, Scopus, ResearchGate, and NCBI search sites. Inclusion and exclusion criteria were used to eliminate unrelated literature, resulting in 23 pieces of literature. Discussion: Based on phytochemical screening, S. polyanthum leaves and A. paniculata leaves contain compounds with beneficial effects in modulating the metabolic profile of T2DM patients by reducing oxidative stress, inhibiting ?-glycosidase, increasing insulin levels, regenerating pancreatic ?-cells, increasing glycolytic enzyme activity, and reducing pro-inflammatory biomarker levels. Conclusion: The mixture of aqueous extracts of S. polyanthum and A. paniculata leaves or combined with conventional drugs in the treatment of T2DM showed significant antidiabetic effects.
Peran Penerapan Program Vaksinasi HPV dengan Optimalisasi Skrining dan Pengobatan Kanker Serviks sebagai Strategi Ambisius Penurunan Prevalensi Kanker Serviks di Negara-Negara Berkembang: Sebuah Tinjauan Pustaka Meidina, Adinda Nezma; Putri, Yolanda Delia; Nugraha, M. Aditya; Fadhlan, Muhammad Muhadzdzab; Ramadhanti, Nafilah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 3 (2025): Vol. 11 No. 3 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 1
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i3.780

Abstract

Background: Cervical cancer is the fourth most common type of cancer in women in the world, with 94% of total deaths worldwide occurring in developing countries in 2022. In response to this problem, WHO initiated a movement to eliminate cervical cancer, known as the 90-90 strategy, through implementing vaccination programs and optimizing screening and treatment for cervical cancer cases. This literature review aims to describe the role of these strategies in eliminating cervical cancer, especially in developing countries. Methods: Literature was searched using search sites such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were used to eliminate unrelated literature to obtain 36 literature. Discussion: HPV vaccination has been proven to provide protective benefits in reducing the incidence of neoplastic lesions and shows a relatively decreasing trend in the group receiving the vaccine. Cervical screening plays a very important role in the early detection and therapy of precancer, which shows a trend in preventing cancer cases in the next 50 years. Modeling studies show that successful implementation of the WHO 90-70-90 intervention by 2030 will reduce the incidence of cervical cancer to 0.7 per 100,000 women and the death rate to 0.2 per 100,000 women in all developing countries. Conclusion: The implementation of the HPV vaccination program with the optimization of cervical cancer screening and treatment is believed to be a solution modality to reduce morbidity and mortality rates due to cervical cancer in the world, especially in developing countries.
Potensi Teknologi Nanopartikel Logam Seng Oksida (NP-ZnO) pada Obat Anti-TB Sebagai Modalitas Mutakhir Pengobatan Penyakit Multidrug-Resistant Tuberculosis (MDR-TB) Meidina, Adinda Nezma; Triandra, Akbar; Hasibuan, Nabila Az-zahra; Fajri, M. Alif Al
SCRIPTA SCORE Scientific Medical Journal Vol. 5 No. 2 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v5i2.15230

Abstract

Background: Tuberculosis (TB) is a treatable infectious disease caused by the Mycobacterium tuberculosis pathogen. However, patient non-compliance during treatment contributes to the emergence of Multidrug-resistant Tuberculosis (MDR-TB). This literature review aims to further explore the potential of zinc oxide metal nanoparticles (NP-ZnO) in anti-TB drugs as an advanced modality for MDR-TB treatment by enhancing drug efficacy, reducing intestine degradation, and increasing absorption and bioavailability. Methods: Literature was searched using search engines such as Google Scholar, Science Direct, ResearchGate, and NCBI. Inclusion and exclusion criteria were applied, resulting in 14 relevant articles. Results and Discussion: Zinc oxide metal nanoparticles (NP-ZnO) exhibit antibacterial effects. Studies show that NP-ZnO can decrease Rifampicin's minimum inhibitory concentration (MIC) fourfold by enhancing bacterial cell membrane permeability and increasing bactericidal effects through interactions with host macrophage cells. Bactericidal effects were found with NP-ZnO and its combination with selenium (NP ZnO-Se). Meanwhile, bacteriostatic effects on MDR-TB and XDR-TB were observed with NP-ZnO and its combination with silver (NP Ag-ZnO). Conclusion: NP-ZnO encapsulated first-line anti-TB drugs offer advantages in delivering medication to target organs, accelerating therapy onset even with smaller doses, and mimicking M.tb's activity in infecting target organs. NP-ZnO and its combinations are also more sensitive in interacting with alveolar macrophages, the first immune cells responding to M.tb. NP-ZnO encapsulated first-line anti-TB drug technology holds potential as an advanced modality for MDR-TB treatment. Keyword: First-line anti-TB drugs, metal nanoparticle, multidrug-resistant tuberculosis, zinc oxide nanoparticle   Latar Belakang: Tuberkulosis (TBC) merupakan penyakit menular yang disebabkan oleh patogen Mycobacterium tuberculosis (M.tb) dan dapat diobati, tetapi rendahnya kepatuhan pasien selama pengobatan berdampak pada timbulnya Multidrug-resistant Tuberculosis (MDR-TB). Tinjauan literatur ini bertujuan untuk meninjau lebih lanjut potensi teknologi nanopartikel logam seng oksida (NP-ZnO) pada obat anti-TB sebagai modalitas mutakhir pengobatan penyakit MDR-TB dengan meningkatkan kemanjuran obat yang diberikan, mengurangi degradasi usus, serta meningkatkan absorpsi dan bioavailabilitas. Metode: Literatur dicari menggunakan situs pencari seperti Google Scholar, Science Direct, ResearchGate, dan NCBI. Kriteria inklusi dan eksklusi digunakan untuk mengeliminasi literatur yang tidak berkaitan sehingga diperoleh 14 literatur. Hasil dan Pembahasan: Nanopartikel logam seng oksida (NP-ZnO) menunjukkan efek antibakteri. Studi ini menunjukkan NP-ZnO dapat menurunkan minimum inhibitory concentration (MIC) rifampisin empat kali lipat dengan meningkatkan permeabilitas membran sel bakteri serta meningkatkan efek bakterisida melalui interaksinya dengan makrofag sel inang. Efek bakterisida ditemukan pada NP-ZnO dan kombinasinya dengan selenium (NP ZnO-Se). Sementara itu, efek bakteriostatik MDR-TB dan XDR-TB ditemukan pada NP-ZnO dan kombinasinya dengan perak (NP Ag-ZnO). Kesimpulan: Obat anti-TB lini pertama terenkapsulasi NP-ZnO memiliki keunggulan dalam penghantaran obat ke organ target, mempercepat onset terapi walau dengan dosis yang lebih kecil, dan meniru aktivitas M.tb dalam menginfeksi organ target. NP-ZnO maupun kombinasinya juga lebih sensitif dalam berinteraksi dengan makrofag alveolar yang merupakan sel imun pertama yang merespons M.tb. Teknologi obat anti-TB lini pertama terenkapsulasi NP-ZnO berpotensi sebagai modalitas mutakhir pengobatan MDR-TB. Kata Kunci: Multidrug-resistant tuberculosis, nanopartikel logam, nanopartikel seng oksida, obat anti-TB lini pertama
Co-Authors Dapala, Zelka Fadhlan, Muhammad Muhadzdzab Fajri, M. Alif Al Fareza, M. Daffa Hasibuan, Nabila Az-zahra Istiqomah, Dyah Fatha Muftaridi, Rajwa Fairuz Putri Nugraha, M. Aditya Putri, Yolanda Delia Ramadhanti, Nafilah Riza, M. Aidil Tarensyah Triandra, Akbar