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All Journal Cendekia Journal of Pharmacy Jurnal Syntax Fusion : Jurnal Nasional Indonesia
Wulandari, RR Sri
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Education Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences

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PENGARUH TRANSCUTOL P DAN PEG 400 DALAM PEMBUATAN TABLET LIQUISOLID NIFEDIPIN TERHADAP MUTU FISIK DAN DISOLUSI Kuncahyo, Ilham; Hutami, Shabrina Nindya; Wulandari, RR Sri
Cendekia Journal of Pharmacy Vol 9, No 1 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i1.330

Abstract

Nifedipine as a hypertension drug has the problem of low solubility (BCS class II), leading to decreased dissolution and bioavailability. Formulation of nifedipine liquisolid using non-volatile solvents can overcome this problem. This study aimed to evaluate the effect of Transcutol P and PEG 400 as non-volatile liquisolid ingredients on the physical quality and dissolution of nifedipine liquisolid tablets. This study used seven nifedipine liquisolid formulations, each with varying concentrations of Transcutol P or PEG 400 as non-volatile solvents and lactose as carrier material. Formula 1 (20% Transcutol: 80% lactose), Formula 2 (25% Transcutol: 75% lactose), Formula 3 (30% Transcutol: 70% lactose), Formula 4 (20% PEG 400: 80% lactose), Formula 5 (25% PEG 400: 75% lactose), Formula 6 (30% PEG 400: 70% lactose), and one control formula. The nifedipine liquid produced from each formula was forged into tablets using the direct felting method with a weight of approximately 200 mg. The tablets were tested for physical quality and dissolution, and the results were statistically analyzed using SPSS version 12.0. The results showed that Transcutol P and PEG 400 as liquisolid ingredients for nifedipine tablets provided good physical quality and improved the quantity and rate of drug release. The effect of PEG 400 as a liquisolid material for nifedipine tablets slowed down the disintegration time and accelerated the dissolution rate compared with Transcutol P. The dissolution profile showed that the release of nifedipine tablets with PEG 400 liquisolid material reached 30% at the fifth minute, meeting the requirements according to Indonesian Pharmacopoeia VI, which stipulates that more than 75% should be released at the sixtieth minute
Peningkatan Pengetahuan Masyarakat Tentang Pemanfaatan Tanaman Herbal Dalam Rangka Pencegahan Penyakit Diabetes Mellitus Wulandari, RR Sri; Prawistya Sari, Agnes; Triana, Lanny; Wardhana Amrullah, Adhi
Jurnal Syntax Fusion Vol 3 No 03 (2023): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : CV RIFAINSTITUT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v3i03.281

Abstract

Diabetes is a chronic disease with an increasing prevalence and a threat to global health. Many people are still not aware of the importance of maintaining health in order to prevent degenerative diseases in old age. Moreover, nowadays there are so many ready-to-eat foods that have the potential to cause many diseases, one of which is diabetes mellitus. The community service team provides counseling to increase understanding and insight into the importance of using herbal medicine in the context of preventing diabetes mellitus. The results of community service counseling attended by 30 participants can be concluded that with this counseling the community is very enthusiastic and welcomes this activity as seen from the questions raised. This activity provides insight for the people of Gumpang Village, especially the types of herbal plants that can lower blood glucose levels.
Co-Authors Hutami, Shabrina Nindya Ilham Kuncahyo, Ilham Prawistya Sari, Agnes Triana, Lanny Wardhana Amrullah, Adhi