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All Journal IDJP (Indonesian Journal of Pharmaceutics)
Farisa Desy Arya, Insi
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 A Comparative Study on The Therapeutic Effect of pH, Temperature Triggered, and Ion Activated In Situ Gelling System For Ocular Delivery Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Budiman, Arif; Zubaidah, and
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.52695

Abstract

One of the most popular pharmaceutical preparations for the eyes today is in situ gel. The in situ gel system is a system that is liquid at room temperature but will form a gel when it comes into contact with the body or undergoes a change in pH. The form of the drug delivery system is in-situ is a type of mucoadhesive drug delivery system. Gel formation depends on several factors such as temperature modulation, pH changes, the presence of ions, ultra-violet irradiation, electrical sensitivity, and the enzyme by which the active substance is released. The purpose of this study is to compare the therapeutic efficacy of in situ gel medicines on pH, temperature triggered, and ion activated gelling systems. A drug in situ gel is a drug delivery device that transforms into a gel after being applied to the body. The findings revealed that the pH, temperature triggered, and ion activated gelling system factors had a substantial influence on the extended release medicines that affect the therapeutic effect of in situ gel medications. This comparative investigation demonstrates that the pH, temperature triggered, and ion activated gelling system factors have significant implications on the therapeutic benefits of in situ gelled medicines. A deeper knowledge of the relationships between these variables and in situ gel drug delivery methods can lead to the development of more effective and dependable medication compositions. These findings could aid in the development of improved gel in situ drug delivery systems to improve therapeutic benefits in the treatment of a variety of medical disorders.  Keywords: in situ gel, pH triggered, temperature triggered, ion activated, therapeutic effect.
 A Concise ReviewThe Ph Triggered Concept In Situ Ophthalmic Gel Of Sodium Cromoglycate, Diclofenac Sodium and Aceclofenac Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Sopyan, Iyan
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.52748

Abstract

The ophthalmic solutions have a major problem that is the poor bioavailability, such as the attainment of optimal drug concentration at the site of action, which is compromised mainly due to precorneal loss resulting in only small fraction of the drug being ocularly absorbed. This is overcome by developing an in situ ophthalmic gel which increases the retention time of the drug. The present review describes the formulation and evaluation of in situ gel-forming ophthalmic drug delivery system of an anti allergy drug sodium cromoglycate, an anti-inflammatory drug diclofenac sodium and aceclofenac based on the pH triggered concept in situ gelation. All the formulations varies in concentration and the content used. Based on the results obtained, Sodium cromoglycate which has been formulated with gelrite and HPMC E15LV has the highest ocular residence time compared to the other two formulations.Keywords: Ophthalmic in situ gel,sodium cromoglycate, diclofenac sodium,                      aceclofenac, gelrite, HPMC E15LV
Co-Authors Arif Budiman Insan Sunan Kurniawansyah, Insan Sunan Iyan Sopyan Zubaidah, and