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All Journal Journal of Scientech Research and Development International Journal Of Health And Social Behavior
Ni Luh Wisma Eka Yanti
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Humanities Computer Science & IT Education Health Professions Industrial & Manufacturing Engineering Nursing Public Health Social Sciences

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Harnessing Stem Cells for Kidney Regeneration : Progresses and Challenges in Clinical Translation Ni Luh Wisma Eka Yanti; Anak Agung Dita Hendrawan; Maqfirah Muryanifa
International Journal of Health and Social Behavior Vol. 2 No. 1 (2025): February: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i1.282

Abstract

The prevalence of chronic kidney disease is increasing worldwide and is considered a burden for health care systems and patients. However, there are only a few treatment options, and in most cases, the end-stage of the disease requires renal replacement. Stem cell-based therapy has gained popularity as a cutting-edge strategy in the field of regenerative nephrology. Numerous clinical studies on evaluating stem cells safety and tolerability have been carried out, leading to clinical translation of stem cells for kidney regeneration. This study will focues on progresses of recent clinical trials on stem cell therapy for various kidney diseases, while also highlighting key challenges in clinical translation and future directions in the field of regenerative nephrology.
PHARMACOLOGY OF QUERCETIN IN DIABETIC NEPHROPATHY: A NARRATIVE REVIEW OF PRECLINICAL EVIDENCE Ni Luh Wisma Eka Yanti
Journal of Scientech Research and Development Vol 7 No 2 (2025): JSRD, December 2025
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jsrd.v7i2.1511

Abstract

Diabetic Nephropathy (DN) is a leading cause of end-stage renal disease, characterized by progressive and often irreversible collapse of renal architecture. Given the complex cellular dysfunction involved, therapeutic strategies are shifting toward integrative approaches utilizing compounds with pleiotropic effects. Quercetin is recognized as a pleiotropic molecule capable of exerting diverse and simultaneous biological effects, positioning it as a novel target-based pharmacotherapy for DN management. This narrative review evaluates the pharmacological potential of quercetin as a therapeutic agent for DN, encompassing both in vivo animal models and in vitro cell cultures. Current evidence demonstrates that quercetin effectively mitigates the multifaceted pathogenesis of DN. Key mechanisms include the attenuation of oxidative stress via the Nrf2/HO-1 signaling pathway, the inhibition of ferroptosis, and the suppression of inflammatory markers trough the regulation of NFkB and NLRP3 axis. Furthermore, quercetin preserves renal architecture by preventing podocyte apoptosis, reducing fibrosis, and restoring lipid metabolism dysregulation. Although its clinical application is currently challenged by low oral bioavailability, advanced delivery system such as nanoparticles and liposomes shows significant promise in enhancing therapeutic outcomes.
Co-Authors Anak Agung Dita Hendrawan Maqfirah Muryanifa