Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Medicamento Jurnal Sehat Indonesia (JUSINDO)
I Made Suma Wirawan
Universitas Mahasaraswati Denpasar
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Complete Dissolution of a Small Gallstone After Three Months of Ursodeoxycholic Acid Therapy: A Case Report I Wayan Oka Semara Jaya; Ignasius Adi Dharma; I Made Suma Wirawan
Jurnal Sehat Indonesia (JUSINDO) Vol. 8 No. 2 (2026): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/-.v8i2.532

Abstract

Cholelithiasis is a common biliary tract disorder frequently encountered in clinical practice. Laparoscopic cholecystectomy remains the standard treatment for symptomatic gallstones; however, nonsurgical therapy with ursodeoxycholic acid (UDCA) may be considered for selected patients with small, uncomplicated gallstones. We report the case of a 68-year-old woman who presented with right upper quadrant abdominal pain. Abdominal ultrasonography revealed a solitary gallstone measuring 0.58 cm without evidence of cholecystitis. The patient was treated with ursodeoxycholic acid at a dose of 500 mg daily. Follow-up ultrasonography performed after three months of therapy demonstrated complete resolution of the gallstone. This case highlights that UDCA may serve as an effective nonsurgical treatment option for selected patients with cholelithiasis, particularly those with small solitary gallstones without inflammatory findings. Clinicians should consider UDCA as a therapeutic alternative for patients who are unsuitable for surgery or decline operative intervention, with routine ultrasonographic follow-up recommended to assess treatment response.
The Neuroprotective Effect of Flavonoids in Huntington’s Disease: A Systematic Review Sang Ayu Arta Suryantari; Anak Agung Intan Pramesti; I Made Suma Wirawan; I Gusti Ngurah Mambal Wirajangsa; I Wayan Yudha Wedantha; Ni Putu Elisya Nathania Fidela
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12361

Abstract

Background: Huntington’s disease (HD) is a hereditary neurodegenerative disorder characterized by progressive striatal and cortical neuronal loss, resulting in severe motor, cognitive, and psychiatric deficits for which no disease-modifying therapy currently exists. Flavonoids, abundant polyphenolic phytochemicals, are increasingly recognized for their potent neuroprotective properties, specifically acting as antioxidants, anti-inflammatory agents, and modulators of apoptosis and autophagy.Objective: This systematic literature review was conducted to synthesize and critically evaluate contemporary preclinical evidence regarding the efficacy of flavonoids in animal models of HD.Methods: A comprehensive search was executed across PubMed, ScienceDirect, and MEDLINE databases (2015–2025) using specific keyword combinations. Studies investigating flavonoid effects in HD animal models with full-text availability were included, whereas publications older than ten years and review studies were excluded. Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. Twelve eligible animal studies were identified, demonstrating methodological quality ranging from good to very good.Results: Consistent findings indicated that flavonoid administration significantly enhanced motor coordination and cognitive performance, attenuated oxidative stress and neuroinflammation, and preserved neuronal integrity. These protective outcomes were mediated through the modulation of multiple molecular pathways, encompassing antioxidant defense systems, inflammatory signaling cascades, and apoptosis-related mechanisms.Conclusion: While current preclinical evidence is promising, underscoring the critical roles of flavonoids as multifaceted neuroprotective agents, further rigorously designed clinical trials are imperative to validate these findings and establish the therapeutic potential and clinical applicability of flavonoids for patients suffering from Huntington’s disease.
Co-Authors Anak Agung Intan Pramesti I Gusti Ngurah Mambal Wirajangsa I Wayan Oka Semara Jaya I Wayan Yudha Wedantha Ignasius Adi Dharma Ni Putu Elisya Nathania Fidela Sang Ayu Arta Suryantari