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Jain, Anvesh
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Medicine & Pharmacology

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AN OVERVIEW ON DOSAGE FORM: SUPPOSITORY Jain, Anvesh; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 01 (2025) Jan 2025
Publisher : Journal of Global Pharma Technology

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Abstract

In this article we converse about various aspects of suppositories such as their introduction, formulations and therapeutic applications. Suppositories are those type of dosage forms that used to provide medication via the vaginal and rectal routes. Before the invention of suppository, liquid enema was used. Enema’s has a big disadvantage that it leaks out of the cavity where it is inserted. Therefore an alternate method of medication was needed and thus suppository was invented. Suppositories can be described as semi-solid dosage form to provide medications via rectal, vaginal routes where they will melt or dissolve and deliver localized or systemic action. Suppositories are preferred over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very convenient modes for drug delivery. In this article we discuss the fundamental components of suppositories including suppository bases, along with the methods of preparation of suppository. This article also targets to fabricate descriptive information about the advancement of suppositories such as, Bi-layered Suppositories, Hollow Suppositories, Effervescent suppositories, etc. Keywords: Suppositories, Types of Bases, Methods of Preparation, Advancement in suppositories.
AN OVERVIEW ON DOSAGE FORM: SUPPOSITORY Jain, Anvesh; Panwar, Mangal Singh
Journal of Global Pharma Technology Volume 17 Issue 01 (2025) Jan 2025
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this article we converse about various aspects of suppositories such as their introduction, formulations and therapeutic applications. Suppositories are those type of dosage forms that used to provide medication via the vaginal and rectal routes. Before the invention of suppository, liquid enema was used. Enema’s has a big disadvantage that it leaks out of the cavity where it is inserted. Therefore an alternate method of medication was needed and thus suppository was invented. Suppositories can be described as semi-solid dosage form to provide medications via rectal, vaginal routes where they will melt or dissolve and deliver localized or systemic action. Suppositories are preferred over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very convenient modes for drug delivery. In this article we discuss the fundamental components of suppositories including suppository bases, along with the methods of preparation of suppository. This article also targets to fabricate descriptive information about the advancement of suppositories such as, Bi-layered Suppositories, Hollow Suppositories, Effervescent suppositories, etc. Keywords: Suppositories, Types of Bases, Methods of Preparation, Advancement in suppositories.
A COMPREHENSIVE REVIEW OF PHARMACEUTICAL VALIDATION AND QUALIFICATION: CONCEPTS, PRACTICES, AND EVOLVING TRENDS Meena, Manish; Jain, Anvesh; Panwar, Mangal S
Journal of Global Pharma Technology Volume 17 Issue 04 (2025) April 2025
Publisher : Journal of Global Pharma Technology

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Abstract

Pharmaceutical validation is a critical component of current Good Manufacturing Practices (cGMP), ensuring that processes, systems, and methods consistently produce products that meet predetermined quality standards. This review explores the principles and types of validation with a focus on process validation, equipment qualification, analytical method validation, cleaning validation, and computer system validation. Emphasis is placed on the regulatory frameworks provided by agencies such as the FDA and EMA, as well as the lifecycle approach to validation, which includes process design, qualification, and continued verification. The article also highlights recent advancements such as risk-based validation strategies, the use of automation and digital tools, and the implementation of ICH guidelines. By integrating both foundational knowledge and emerging trends, this review provides a strategic overview valuable for quality assurance professionals, regulatory personnel, and pharmaceutical researchers. Keywords: Pharmaceutical Validation, Process Qualification, cGMP, Risk-Based Validation, Lifecycle Approach.
Co-Authors Meena, Manish Panwar, Mangal S Panwar, Mangal Singh