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UJI EFEKTIFITAS EKSTRAK SAFFRON (CROCCUS SATIVUS) SEBAGAI ALTERNATIF DIAZEPAM TERHADAP HEART RATE PADA TIKUS CIRCADIAN RHYTME SLEEP DISORDER (CRSD) Suharni, Suharni; Raditya Pangestu; Tania Putri Zulkifli; M. Ferdi Devilito; Ardi Khusnaidi; Afdila Syarfina
Nusantara Hasana Journal Vol. 4 No. 7 (2024): Nusantara Hasana Journal, December 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i7.1340

Abstract

Circadian rhythm sleep disorder (CRSD) is a problem that affects people from waking to sleep. There are many ways to reduce the intensity of CRSD; one of them is by taking diazepam. However, the side effects of Diazepam are much more dangerous. Therefore, it is important to use herbal medicines as traditional medicines to maintain health so that they are safe for consumption, one of which is using turmeric (Crocus sativus). This research was conducted at the Pharmacy Laboratory, Universitas Perintis Indonesia. The goal of this study was to compare the average heart rate of rats treated with saffron and diazepam for sleep disorders. Turmeric extract and diazepam were given orally at a dose of 50 mg/KgBB and diazepam at a dose of 0.75 mg/KgBB, and 15 rats were used. Measurement of rats heart rate was carried out on the 1st, 7th, and 14th days. The results of the study concluded that the treatment of experimental animals by presenting saffron and diazepam extracts was able to reduce the average heart rate value in each rats, with data analysis showing that there was a significant difference in the heart rate of each with a value of P = 0.015 (P < 0.05). So it can be said that the use of saffron extract is effective in overcoming CRSD.
Analisis Dinasti Fathimiyah di Mesir : Pertumbuhan, Perkembangan, dan Kemajuan Rosidah Rosidah; Ratnasari Ratnasari; Yunan Fahri Ramadhan; Raditya Pangestu; Ahmad Maftuh Sujana
Moral : Jurnal kajian Pendidikan Islam Vol. 2 No. 2 (2025): Juni : Moral : Jurnal kajian Pendidikan Islam
Publisher : Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/moral.v2i2.948

Abstract

This article explores the political, religious, and socio-cultural dimensions of the Fatimid Dynasty's rule in Egypt, highlighting its unique contributions to Islamic civilization. The Fatimid Caliphate, which ruled from 969 to 1171 AD, represented a significant Shi'a Islamic power that challenged the dominance of the Sunni Abbasid Caliphate. The study analyzes the origins of the Fatimid dynasty, its establishment in North Africa, and its eventual relocation of the capital to Cairo, which became a vibrant center of learning and governance. Special attention is given to the administrative reforms, religious tolerance policies, and architectural advancements initiated by Fatimid rulers. Additionally, the article examines the tensions and conflicts both internally and externally that eventually led to the dynasty’s decline. By using historical and historiographical methods, this research aims to provide a comprehensive understanding of how the Fatimid Dynasty shaped the political and religious landscape of medieval Egypt and left a lasting legacy that can still be seen in Egyptian culture and architecture today.