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All Journal Indonesian Journal of Cancer Chemoprevention
Eskandar, Kirolos
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Nanotechnology in Cancer Treatment: Innovative Approaches to Overcoming Drug Resistance in Tumors Eskandar, Kirolos
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp162-174

Abstract

Nanotechnology has emerged as a groundbreaking approach in oncology, offering innovative solutions to one of the most significant challenges in cancer treatment: drug resistance. This literature review explores the role of nanotechnology in overcoming multidrug resistance (MDR) in tumors, focusing on the use of nanoparticles for targeted drug delivery, gene therapy, and immunotherapy. By penetrating biological barriers and modulating the tumor microenvironment, nanocarriers enhance the efficacy of anticancer agents while minimizing side effects. Additionally, this review provides a comprehensive analysis of recent clinical trials, offering insights into the real-world effectiveness of nanotechnology-based treatments. Ethical, regulatory challenges, and nanotoxicity are discussed to ensure the safe translation of nanomedicine to clinical practice. The review concludes with future directions in personalized nanomedicine, highlighting nanotechnology’s transformative potential in revolutionizing cancer treatment and improving patient outcomes by addressing the pervasive issue of drug resistance.Keywords: nanotechnology, drug resistance, nanoparticles, targeted drug delivery, cancer therapy.
Neoadjuvant and Adjuvant Surgical Interventions in Oncology: Optimizing Treatment Pathways Eskandar, Kirolos
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp237-250

Abstract

The advancement of cancer treatment has seen significant progress through the integration of neoadjuvant and adjuvant therapies, particularly within the realm of surgical oncology. This literature review follows a systematic approach using PRISMA guidelines, analyzing studies from databases such as PubMed, Google Scholar, Scopus, and Web of Science. The review examines the historical progression, current practices, and future directions of multimodal approaches, focusing on the synergistic benefits of surgery, drug development, targeted therapies, and technological innovations. Neoadjuvant interventions, designed to shrink tumors preoperatively, enhance surgical outcomes by improving resectability, while adjuvant therapies, administered postoperatively, aim to eliminate residual disease and reduce recurrence risk. Findings from clinical trials and case studies highlight improved survival rates, increased tumor resectability, and enhanced patient outcomes through the combination of these therapies. Additionally, the review emphasizes the crucial role of personalized medicine, molecular profiling, and emerging surgical technologies in refining treatment pathways. As the landscape of cancer care evolves, optimizing treatment sequencing and tailoring therapies to individual tumor profiles will be essential for maximizing therapeutic efficacy and improving patient prognosis.Keywords: Neoadjuvant Therapy, Adjuvant Surgical Intervention, Surgical Oncology, Multimodal Cancer Treatment, Targeted Cancer Therapy.
CAR-T Cell Therapy: Revolutionizing Cancer Treatment Eskandar, Kirolos; Sayh, Melad
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp76-86

Abstract

CAR-T cell therapy has emerged as a groundbreaking approach in cancer treatment, offering new hope for patients with refractory and relapsed malignancies. This literature review provides a comprehensive overview of the development, applications, and future directions of CAR-T cell therapy. We explore the principles behind CAR-T cell engineering, highlight the clinical successes and challenges in treating hematologic malignancies, and discuss the potential and hurdles in targeting solid tumors. The review also examines the safety profiles, including adverse effects management, and delves into the mechanisms of resistance and relapse. Furthermore, we address regulatory and ethical considerations, patient perspectives, and the innovative advancements shaping the future of CAR-T cell therapy. By synthesizing current research and clinical data, this review underscores the transformative impact of CAR-T cell therapy in oncology and its promising trajectory in the fight against cancer.Keywords: CAR-T cell therapy, cancer treatment, hematologic malignancies, solid tumors, next-generation CAR-T.
Co-Authors Sayh, Melad