<![CDATA[The high number of dengue fever cases in Indonesia will reach an increase of 30% in 2022, which can cause death, which is caused by the Aedes aegypty mosquito vector. Control and eradication of the Aedes aegypti mosquito is generally carried out using chemical insecticides. However, continued use of chemical insecticides can cause resistance in vector mosquitoes and have negative impacts on the environment. Papaya leaves (Carica papaya L.) have long been known to have various health benefits, including as a traditional medicine for dengue fever which contains active compounds such as flavonoids, alkaloids, saponins and the enzyme papain. The aim of this research was to analyze the effect of papaya leaf extract concentration (Carica papaya L.) on the mortality of Aedes aegypti mosquito larvae. This type of research is a laboratory experiment, carried out at the FK UNPRI Laboratory. The population in this study was 30 Aedes Aegypty mosquito larvae and the samples used were extracts from papaya leaves (Carica Papaya L) with concentrations of 15% and 85%. The sample collection technique uses purpose sampling technique. Data were analyzed using the Kruskal-Wallis test. The results can be concluded that papaya leaf extract (carica papaya L) at a concentration of 85% is proven to be effective against the death of Aedes aegypti larvae. (p = 0.379 )with the LD50 equation within a 2 hour minimum period to kill Aedes aegypti larvae. The higher the dose of papaya leaf extract will result in a greater number of larval deaths.]]>
