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All Journal Bioma : Jurnal Biologi Indonesia
Supriyatin
Universitas Negeri Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Leaf area and stomatal density of Rhizophora mucronata Poir. under high and low light environment of Nature Tourism Park Angke-Kapuk, Jakarta, Indonesia Bagus Tito Wibisono; Tri Wahyuni; Murniati Simanjuntak; Abizar; Supriyatin
Bioma Vol. 20 No. 2 (2024): BIOMA
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/bioma.v20i2.49339

Abstract

Each type of mangrove has specific stomatal characteristics, one of which is stomatal density. This stomatal density is directly proportional to the rate of evaporation, transpiration, and photosynthesis which is a form of mangrove adaptation to its environment. One of the external factors affecting stomatal density is light intensity which can vary due to canopy cover. This study aims to compare the stomatal density of Rhizophora mucronata Poir. in the Angke-Kapuk area, Jakarta, Indonesia. The location is a mangrove conservation area that has experienced a lot of environmental pressure, especially due to population growth and land conversion into settlements. Descriptive methods was used with transect sampling techniques at locations that represent very open and very closed canopies determined by purposive sampling. Stomatal sampling was carried out by applying a transparent nail polish on the lower surface of the leaf and then covering it with tape. The tape was observed using a microscope, and showed that Rhizophora mucronata Poir. has a low stomatal density. The results of the parametric independent sample t-test showed that the stomatal density of Rhizophora mucronata was not significantly different between very open and very closed canopy cover.
In Silico Study of the potency of Drynaria rigidula (Sw.) Bedd. (Polypodiaceae) compounds in breast cancer therapy targeting AKT1 protein pathways Naufal Ma'arif; Sefti Adelia; Alifia Dwinanti Hakamashe; Fadila Nur’anfa Putri; Nailul Rahmi Aulya; Supriyatin
Bioma Vol. 20 No. 2 (2024): BIOMA
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/bioma.v20i2.49340

Abstract

Breast cancer is the second most prevalent cancer globally. One of the key pathways involved in breast cancer is the PI3K/Akt mechanism. A natural compound with potential that has not been extensively studied is Drynaria rigidula (Sw.) Bedd., a Polypodiaceous fern native to Indonesia and is commonly used in traditional medicine. This study aims to explore the potential of Drynaria rigidula as an anti-breast cancer agent. The method used in silico analysis by collecting data from several web servers such as SwissADME (https://www.swissadme.ch/) with the parameters Lipinski’s rule of five, Veber, Egan, and Way2Drug for biological activity. The protein used in this study is AKT1 (PDB ID: 6HHF), obtained from the RCSB database. Molecular docking analysis was conducted using PyRx software with visualization performed in Biovia Discovery Studio. The results showed that several compounds, such as 3,4-dihydroxybenzoic acid, fern-9(11) ene, Stigmasterol, dan Campesterol, had RMSD values < 3.0 Å and binding affinities of -9.4, -9.2, -7.6, and -7.6 respectively. These results were compared with the control ligand AZD5363 and doxorubicin, which had a binding affinity from each other are -8.3 and -7.4. Therefore, the docking results indicate that compounds from Drynaria rigidula are predicted to have potential as anti-cancer agents.
Co-Authors Abizar Alifia Dwinanti Hakamashe Aulya, Nailul Rahmi Bagus Tito Wibisono Fadila Nur’anfa Putri Murniati Simanjuntak Naufal Ma'arif Sefti Adelia Tri Wahyuni