The textile industry is one of the most important manufacturing sectors in Indonesia; however, it faces significant challenges related to production waste and resource inefficiency. The adoption of Industry 4.0 technologies, particularly the Internet of Things (IoT) and Digital Twin, has emerged as a promising solution for improving operational efficiency and supporting sustainable manufacturing practices. This study aims to analyze the impact of IoT implementation and Digital Twin implementation on waste reduction in the textile industry in Bandung. A quantitative research approach was employed using a survey method involving 75 respondents from textile manufacturing companies. Data were collected through a structured questionnaire measured using a five-point Likert scale and analyzed using SPSS version 25. The analytical techniques included validity and reliability tests, classical assumption tests, multiple linear regression analysis, coefficient of determination analysis, and hypothesis testing. The results indicate that IoT implementation has a positive and significant effect on waste reduction. Similarly, Digital Twin implementation positively and significantly affects waste reduction. Furthermore, the simultaneous test demonstrates that IoT and Digital Twin implementation jointly influence waste reduction. The coefficient of determination (R² = 0.697) indicates that 69.7% of the variation in waste reduction can be explained by the two independent variables. These findings suggest that the integration of IoT and Digital Twin technologies enhances operational visibility, predictive decision-making, and process optimization, thereby reducing production waste in textile manufacturing. The study contributes to the growing literature on Industry 4.0 and provides practical insights for textile companies seeking to improve sustainability and operational efficiency through digital transformation.