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All Journal JURNAL KIMIA SAINS DAN APLIKASI
Mochamad Fathurohman
Department of Pharmacy, Faculty of Pharmacy, Bakti Tunas Husada University, Tasikmalaya|Bakti Tunas Husada University|Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering

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Validation of the Use of Anthocyanin as Indicators for Acid-Base Titration Lilis Tuslinah; Laras Rizkia Widyastuti; Mochamad Fathurohman
Jurnal Kimia Sains dan Aplikasi Vol 28, No 2 (2025): Volume 28 Issue 2 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.2.53-61

Abstract

Rambutan peel (Nephelium lappaceum L.) contains secondary metabolites, particularly flavonoids, including anthocyanins. Anthocyanins exhibit color changes in response to variations in pH, making them potential candidates for use as acid-base indicators. This study aims to validate using methanol fraction powder derived from rambutan peel as an acid-base titration indicator by evaluating method validation parameters such as precision, accuracy, and linearity. The fractionation process was conducted using liquid-liquid extraction with n-hexane, water, and methanol as solvents, followed by freeze-drying of the methanol fraction. The methanol fraction powder was analyzed and compared with the conventional phenolphthalein indicator to determine the color transition at the titration endpoint. The results indicated that the methanol fraction exhibited a color change to brown within a pH range of 8–11. Statistical analysis using an independent sample t-test showed no significant difference between the methanol fraction powder and phenolphthalein (significance value > 0.05). Therefore, based on the method validation results, including precision, accuracy, and linearity, the methanol fraction powder of rambutan peel demonstrates potential as a reliable acid-base indicator.
Copigmented Butterfly Pea Flower Extract (Clitoria ternatea L.) as an Antibacterial Agent against Propionibacterium acnes and Its Formulation in Microneedle Patches Lilis Tuslinah; Adita Diari Fanisa; Mochamad Fathurohman
Jurnal Kimia Sains dan Aplikasi Vol 29, No 5 (2026): Volume 29 Issue 5 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.5.328-337

Abstract

Acne vulgaris is a common skin condition often caused by a bacterial infection with Propionibacterium acnes. The extract of butterfly pea flower (Clitoria ternatea L.) contains anthocyanins and other bioactive compounds that have potential as antibacterial agents. Anthocyanins are unstable to heat and light; thus, copigmentation with 1.2% citric acid was performed to maintain their stability. This study aims to evaluate the antibacterial potential of the copigmented extract and to characterize the hyaluronic acid- based microneedle patch formulation as a transdermal delivery system, including organoleptic tests, mechanical tests, and morphology using Scanning Electron Microscopy (SEM), as well as the antibacterial potential of the formulation. The results showed an extract yield of 55.45% with an anthocyanin content of 2.9668 mg/L (expressed as cyanidin-3-glucoside equivalents in the analytical solution), with an inhibition zone classified as strong (10–20 mm), and ANOVA analysis indicated significant differences among concentrations (p = 0.032). The microneedle patch formulation exhibited needle deformation following a standardized 32 N compression test (from 395 ± 1.67 µm to 291 ± 17.56 µm), but showed antibacterial activity with an inhibition zone of 12.82 ± 0.07 mm, classified as strong, and was significantly different from the negative control (p = 0.032).
Co-Authors Adita Diari Fanisa Laras Rizkia Widyastuti Lilis Tuslinah