Purwowiyoto, Sidhi Laksono
The Indonesian Heart Association

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Journal : YARSI Medical Journal

Kardiomiopati Dilatasi pada Pasien HIV-AIDS Purwowiyoto, Sidhi Laksono
Jurnal Kedokteran YARSI Vol 26, No 1 (2018): JANUARI - APRIL 2018
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1521.336 KB) | DOI: 10.33476/jky.v26i1.363

Abstract

The heart and great vessels are not the sites most frequently affected by opportunistic infections and neoplastic processes in patients with acquired immune deficiency syndrome (AIDS). HIV-related disease is now recognized as an important cause of dilated cardiomyopathy, with a prevalence of 8%–30%. Patients with HIV-infection and dilated cardiomyopathy have a much worse prognosis than those with idiopathic dilated cardiomyopathy. Cardiac involvement in HIV represents a pathophysiologic, diagnostic and therapeutic challenge for cardiologists. This review describes pathophysiology, diagnosis, treatment and prognosis of HIV- dilated cardiomyopathy.
Obstructive Sleep Apnea dan Gagal Jantung Purwowiyoto, Sidhi Laksono
Jurnal Kedokteran YARSI Vol 25, No 3 (2017): SEPTEMBER - DESEMBER 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (686.544 KB) | DOI: 10.33476/jky.v25i3.364

Abstract

Obstructive sleep apnea (OSA) is a part of sleep-disordered breathing which is commonly found in the population of heart failure. Epidemiological studies have shown significant independent associations between OSA and heart failure. OSA plays an important role in the pathogenesis and progression of heart failure. Several pathogenesis are the mechanical effect, activation of sympathetic, inflammation process, and endothelial dysfunction. These can impair myocardial contractility and cause development and progression of heart failure. However, the prevalence OSA is only the “tip of the iceberg” due to the difficulty in diagnosis. Most of OSA patients, particularly in the heart failure population, have no complaint of the sleepiness.