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All Journal Jurnal Medika Malahayati MAHESA : Malahayati Health Student Journal
Bawono, Mada Ilham
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Efektivitas Pemberian Platelet-Rich Plasma Pada Wanita Dengan Endometrium Tipis: Tinjauan Sistematis Literatur Bawono, Mada Ilham; Mufidah, Belinda
Jurnal Medika Malahayati Vol 9, No 1 (2025): Volume 9 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v9i1.18257

Abstract

Penelitian ini bertujuan untuk mengevaluasi efektivitas pemberian Platelet-Rich Plasma (PRP) pada perempuan dengan endometrium tipis melalui systematic literature review. endometrium tipis merupakan tantangan utama dalam teknik reproduksi buatan karena berhubungan dengan rendahnya Implantation Rate (IR), Chemical Pregnancy Rate, Clinical Pregnancy Rate (CPR), dan Live Birth Rate (LBR). Metode penelitian melibatkan pencarian literatur pada database PubMed, Google Scholar, Sciencedirect, dan Springer dengan kriteria inklusi dan eksklusi yang ketat. Kata kunci yang digunakan meliputi “ICSI”, “IVF”, “Intracytoplasmic Sperm Injection”, “In Vitro Fertilization”, “PRP”, “Platelet-Rich Plasma”, dan “Thin Endometrium”. Jumlah studi yang disertakan dalam analisis adalah 12 studi, yang terdiri dari studi interventional cohort dan Randomised Control Trial (RCT). Hasil analisis menunjukkan bahwa pemberian PRP secara signifikan meningkatkan Endometrial Thickness (EMT), Implantation Rate (IR), Chemical Pregnancy Rate, Clinical Pregnancy Rate (CPR), dan Live Birth Rate (LBR). Namun, peningkatan pada LBR tidak signifikan secara statistik. Sebagian besar penelitian yang dianalisis adalah studi interventional cohort, yang rentan terhadap bias dan memiliki kekuatan bukti yang lebih rendah dibandingkan dengan randomized controlled trial (RCT). Oleh karena itu, diperlukan penelitian lebih lanjut dengan desain RCT yang baik untuk menguatkan temuan ini dan mengeksplorasi lebih lanjut pengaruh pemberian PRP terhadap LBR pada wanita dengan endometrium tipis. Penelitian ini diharapkan memberikan kontribusi signifikan dalam pengembangan terapi baru untuk mengatasi masalah endometrium tipis dalam teknologi reproduksi berbantu.
Effectiveness of Various Maintenance Therapy in Ovarian Cancer A Scoping Review Bawono, Mada Ilham; Mufidah, Belinda
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17551

Abstract

ABSTRACT Ovarian cancer is highly lethal with a lifetime risk of up to 1.1%. Despite advances in treatment like cytoreductive surgery and chemotherapy, high recurrence rates challenge disease management. Maintenance therapy is crucial for extending progression-free survival (PFS) and delaying recurrence. This study aims to evaluate the effectiveness of various maintenance therapies published in the last 10 years, focusing on PARP inhibitors, angiogenesis inhibitors, monoclonal antibodies, and combination therapies. A scoping review was conducted following the PRISMA ScR Protocol. The search was conducted in PubMed, ScienceDirect, and Springer databases. After removing duplicates and applying inclusion and exclusion criteria, 208 articles were screened and 22 articles were selected for final review and critically appraised using the Cochrane RoB 2 tool. This review found that maintenance treatment with PARP inhibitors (e.g., olaparib, niraparib, rucaparib) showed significant improvements in PFS, especially in patients with BRCA mutations and homologous recombination deficiency (HRD). Combination therapies, such as olaparib with bevacizumab, also enhanced PFS. Angiogenesis inhibitors like pazopanib showed variable effectiveness, while monoclonal antibodies like gatipotuzumab had limited success. The combination of pegylated liposomal doxorubicin (PLD) with carboplatin showed potential in improving PFS. These findings highlight the effectiveness of personalized maintenance therapies in extending PFS in ovarian cancer patients. Keywords: Ovarian Cancer, Maintenance Therapy
Co-Authors Mufidah, Belinda