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All Journal Bioeksperimen: Jurnal Penelitian Biologi Journal of Agri-Food Science and Technology (JAFoST)
Magfiroh, Yani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education

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Implementation of Metabolomic Approaches on Fermented Cereals Magfiroh, Yani; Hartajanie, Laksmi; Lindayani, Lindayani; Wulandari, Dyah
Journal of Agri-Food Science and Technology Vol. 6 No. 1 (2025): March
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jafost.v6i1.12610

Abstract

Fermentation is a widely utilized food processing technique that enhances sensory characteristics, extends shelf life, and increases product diversity, particularly in cereals. Furthermore, fermentation processes can generate bioactive metabolites that confer various health benefits. Metabolomics is employed to assess changes in the nutritional composition and metabolite profile of fermented cereal products. This research contributes to identify and synthesize findings from various studies that evaluate the effects of fermentation on the quality of the final product using a metabolomics approach, with particular emphasis on metabolic pathways and the metabolites formed. The research highlights that metabolomics, through sophisticated analytical techniques, has successfully identified metabolites produced during fermentation, which are categorized into volatile compounds (such as organic acids, alcohols, and aldehydes) and non-volatile compounds (including polyphenols, amino acids, fatty acids, free sugars, esters, and amides). These compounds play a pivotal role in enhancing the sensory properties of the product and exhibit bioactive potential that can help prevent the development of metabolic diseases, including diabetes, obesity, digestive disorders, and liver cancer. Despite its potential, the metabolomic approach faces challenges due to the large and intricate datasets it produces. Recent technological advancements have led several studies to incorporate Artificial Intelligence (AI) to enhance the accuracy of data derived from metabolite databases. Moreover, integrating other omics disciplines, such as foodomics, is crucial for achieving more detailed research results, encompassing metabolite composition, sensory attributes, and their effects on health. Such integration would contribute to a more holistic understanding and help bridge the gaps in contemporary metabolomic research.
Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review Magfiroh, Yani
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.23017

Abstract

The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.
Co-Authors Dyah Wulandari HARTAJANIE, LAKSMI Lindayani, Lindayani