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All Journal Pharmacon Jurnal Buana Farma ASSYIFA: Jurnal Ilmu Kesehatan
Syam, Ricky Aditya
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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PERAN APOTEKER KLINIS DALAM MENGATASI DRPS TERAPI ANTIBIOTIK: TINJAUAN SISTEMATIS Syam, Ricky Aditya
ASSYIFA : Jurnal Ilmu Kesehatan Vol. 3 No. 1 (2025)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/ajk.v3i1.132

Abstract

This study aims to explore the role of clinical pharmacy in overcoming drug-related problems (DRPs) related to antibiotic therapy through a systematic literature review. Antibiotics are essential in treating infections, but their increased use also brings new challenges in the form of DRPs that can affect the effectiveness of therapy and patient safety. The method used in this study follows the PRISMA 2020 guidelines by conducting a search in the Wiley and Google Scholar databases for articles published between 2020 and 2025. Of the 103 articles found, seven articles met the inclusion criteria set. The results showed that clinical pharmacists play a critical role in identifying and addressing issues related to antibiotic use. This includes assessing the appropriateness of indications, dosages, and treatment length. The partnership between clinical pharmacists and healthcare teams has resulted in better clinical results. Furthermore, educating patients on the correct use of antibiotics can improve adherence and lower the likelihood of drug-related problems (DRPs). These findings underscore the importance of clinical pharmacist involvement in the management of antibiotic therapy to improve patient safety and treatment effectiveness.
PENGARUH PEMBERIAN ANTIBIOTIK PROFILAKSIS TERHADAP LUARAN BEDAH PADA PASIEN GERIATRI: SISTEMATIK REVIEW Syam, Ricky Aditya
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1351

Abstract

This systematic review examined the effectiveness of prophylactic antibiotic administration in reducing the risk of surgical wound infection in geriatric patients. This topic is of particular importance globally given the rapid increase in the elderly population susceptible to postoperative complications, as well as the variability of the existing evidence regarding the effectiveness and optimal duration of prophylactic antibiotics. Although many studies have been conducted, there has not been a comprehensive synthesis of recent evidence to fill the gap. This study, which is a systematic review based on the PRISMA 2020 guidelines, analyzes articles from the Scopus, PubMed, and Google Scholar databases (2020-2025). The study involved 31 articles that met the inclusion criteria, including retrospective observational studies and randomized clinical trials, with the primary outcomes of postoperative infections and antibiotic-related side effects. The analysis method includes evaluation of the quality of the study as well as narrative and quantitative synthesis. The results showed that the administration of prophylactic antibiotics appropriately significantly reduced the risk of infection, especially in high-risk surgeries such as colorectal, orthopedic, and cardiothoracic, with an optimal duration of about 24 hours postoperatively. The risk of antibiotic resistance and opportunistic infections remains a major concern. The practical implications demand the development of evidence-based guidelines with adjustments to the duration of administration and the strengthening of alternative prevention strategies. Advanced research with a multicenter randomized clinical trial design is essential to optimize prophylactic regimens in diverse and complex elderly populations.
Antibiotic Evaluation of Hospitalized Pneumonia Patients Using Gyssen or DDD 100 Bed Days or DDD 1000 Patient Days: Review Syam, Ricky Aditya; Karuniawati, Hidayah
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23589

Abstract

Pneumonia remains one of the significant infectious diseases in society, especially in developing countries such as Indonesia, with its prevalence continuing to increase year after year. Pneumonia caused by bacteria requires antibiotic treatment, increasing antibiotic use and presenting a risk of antibiotic resistance. Therefore, this study evaluated the use of antibiotics in hospitalized pneumonia patients, with qualitative and quantitative approaches using the Gyssen and ATC / DDD methods. The articles taken as research samples involve a publication period from 2013 to 2023. The data included include the Gyssen parameter, DDD/100, and DDD/1000 patient days. The synthesis showed that ceftriaxone and meropenem antibiotics were the top choices, with values of 1547.735 DDD/100 bed days and 3011.2 DDD/1000 patient days, respectively. Ceftriaxone was documented in 21 journals, while in 8 of 37 journals, meropenem considered antibiotic use in hospitalized pneumonia patients. Evaluation of the quality of antibiotic use showed the highest level in category (0) at 93.7%, followed by (IVa) at 67.6%. Meanwhile, analysis of bacterial resistance to antibiotics showed that Klebsiella pneumonia was the most resistant bacteria, especially to antibiotics carbapenems, ertapenem, doripenem, cephalosporin generation 3, extended-spectrum cephalosporin, and piperacillin/tazobactam, with significant values 0.05%. These findings provide deep insight into patterns of antibiotic use in hospitalized pneumonia patients while identifying potential areas for improving the quality of antibiotic use and treating bacterial resistance. Thus, this study contributes to efforts to optimize pneumonia management and reduce the impact of antibiotic resistance in the community.
Co-Authors Hidayah Karuniawati