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Dinge, Fonny
Universitas Padjadjaran, Indonesia
Medicine & Pharmacology

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Hepatotoxicity Effects of Alcohol Consumption during Paracetamol Therapy of Malaria Patients Dinge, Fonny; Alfian, Sofa D.; Abdulah, Rizky; Sumiwi, Sri A.
Pharmacology and Clinical Pharmacy Research Vol 2, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.442 KB) | DOI: 10.15416/pcpr.v2i2.15244

Abstract

The risk of paracetamol induced hepatotoxicity could increase with alcohol consumption.Paracetamol was usually given to tropical malaria patients to treat fever. The aim of this studywas to determine the hepatotoxicity effect of alcohol consumption in malaria tropica patientsreceiving paracetamol. This study was a cross-sectional study which was conducted duringApril-June 2015 at a hospital in Jayapura, Indonesia. The data were obtained from questionnairesand medical records. Alcohol status was determined by Short Michigan Alcoholics ScreeningTest (SMAST) questionnaire. Level of ALT, AST and bilirubin were observed before and afterreceiving paracetamol therapy for 5 days. Based on the results, the ALT and bilirubin levels ofalcoholic group were higher than in non-alcoholic. However, chi-square test showed that alcoholstatus did not have a significant influence in ALT, AST, and bilirubin levels. Otherwise,logistic regression analysis showed that age gave a significant effect on AST level (P=0.067).Keywords: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alcohol,malaria
Evaluation of Prescription Pattern for Internal Medicines Outpatients using World Health Organization Indicators Dinge, Fonny; Abdulah, Rizky; Sumiwi, Sri A.
Pharmacology and Clinical Pharmacy Research Vol 2, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.952 KB) | DOI: 10.15416/pcpr.v2i3.16216

Abstract

Rational use of drugs plays an important role in efficacy and safety. World Health Organization(WHO) developed a set of indicators to assess medicines precribing pattern. The aim ofthis study was to evaluate the rational use of drugs among internal medicines outpatients ata hospital in Papua, Indonesia, using WHO prescribing indicators. This study was a retrospectiveobservational study conducted during January-March 2014. The data were obtainedfrom patients medical prescriptions. From each prescriptions, data regarding the the totalnumber of drugs, generic, antibiotics, parenteral, and essential drugs were extracted. A totalof 2025 medical precriptions were included in this study. We found out that the averagenumber of drugs per prescription was 2.3. Majority of the prescribed drugs were generic(84.14%). The use of antibiotics, parenteral drugs, and essential drugs were 33.43%, 3.40%,and 60.13%, respectively. Polypharmacy was relatively low among the subjects. The medicinesprescribing patterns among internal medicines outpatients were in accordance withWHO recommendation.Keywords: prescribing indicator, polypharmacy, essential drugs
Co-Authors Rizky Abdulah Sofa D. Alfian, Sofa D. Sumiwi, Sri A.