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All Journal Andalas obstetrics and gynecology journal
Haviz Yuad
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health

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Comparison Of Lactobacillus Plantarum, Lactobacillus Mucosae And Lactobacillus Farciminis Bacteria Between Polycystic Ovary Syndrome And Non Polycystic Ovary Syndrome Students At Medical Faculty Of Andalas University Putri, Mentari Faisal; Haviz Yuad; Andani Eka Putra
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.732-745.2024

Abstract

Background: Polycystic Ovary Syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and morphological features of polycystic ovaries. It is associated with insulin resistance and hyperinsulinemia. Gut microbial dysbiosis plays a role in PCOS, which is associated with insulin resistance, hyperandrogenism, chronic inflammation, and metabolic syndrome. PCOS treatment with Probiotics maintains the stability and diversity of the gut microbiome. Objective: To determine the comparison of Lactobacillus plantarum, Lactobacillus mucosae, and Lactobacillus farciminis Bacteria Between Polycystic Ovary Syndrome and Non Polycystic Ovary Syndrome Students at the Medical Faculty of Andalas University. Method: This research was an analytic observational study using a cross-sectional method conducted on female students with Polycystic Ovary Syndrome and Non-Polycystic Ovary Syndrome at the Medical Faculty of Andalas University. Results: Bivariate analysis of microbiota comparison of female students with PCOS and without PCOS, Mann-Whitney Test on L.mucosae (p=0.774), while Independent T-Test analysis on L.farciminis (p=0.006). Conclusion: There is a decrease in microbiota L. Mucosae in female students with PCOS, but there is no significant difference. There is a significant comparison in the number of microbiota L.farciminis in female students with and without PCOS at FK Unand.
Differences in Vitamin D Receptor Levels Between Women With Primary Infertility and Women Without Infertility Shreshta Dewi; Haviz Yuad; Husna Yetti
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.703-711.2024

Abstract

Introduction: Many studies have been done on vitamin D, but there is still a lack of data regarding Vitamin D receptor (VDR) level and infertility, whereas VDR has a vital role in the action of vitamin D. Objective: To determine the differences in VDR levels between women with primary infertility and women without fertility problems. Method: This is a case-control study on women with and without fertility problems in Padang City, conducted from March 2023–January 2024. Serum VDR levels (ng/ml) were examined using the ELISA method in the Biomedicine Laboratory at Andalas University. Differences in VDR levels were calculated using the independent T-test. Results: There were 60 subjects divided into 30 subjects with infertility and 30 subjects without fertility problems. Subjects with primary infertility had more 31-35 years and >35 years old patients (54.8% and 66.7%), more overweight and obese BMI patients (50% and 83.3%), and had experienced infertility for 1-4 years (73.3%). The mean VDR levels in infertility subjects were lower than in subjects without fertility problems (1.73±0.92ng/ml and 2.35±1.30ng/ml), where this difference was statistically significant (p=0.036). Conclusion: VDR levels influence the incidence of primary infertility.
Gut Microbiota Profile in Endometriosis Patients at Dr. M. Djamil Padang, West Sumatra, Indonesia Haviz Yuad; Utama, Bobby Indra; Lipoeto, Nur Indrawaty; Putra, Andani Eka
Andalas Obstetrics And Gynecology Journal Vol. 9 No. 1 (2025)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.9.1.134-145.2025

Abstract

Objective: Endometriosis (EMS) is a chronic gynecological condition affecting up to 10% of women worldwide. The pathogenesis associated with hormonal imbalance, immune dysregulation, and changes in the gut microbiota. Gut microbiota dysbiosis may drive chronic inflammation that contributes to the progression of EMS. This study hypothesizes that certain gut microbiota profiles are associated with these factors in EMS patients, potentially developing non-invasive diagnostics and more targeted therapies. Methods: This is an observational analytical study with a case-control design conducted at Dr. M. Djamil Padang General Hospital in May 2024 with a sample size of 44 people. Case samples were women aged 18–40 years who were diagnosed with endometriosis based on the inclusion criteria, while the control group were women of reproductive age without a diagnosis of endometriosis. Data testing used the Next Generation Sequencing method, microbiome analysis test, and SPSS test. Results: The majority of EMS patients were aged 30-37 years, married, and had Nullipara obstetric status. In addition, the gut microbiota was dominated by the phyla Bacteroidetes and Firmicutes. Conclusion: There is a relationship between gut microbiota dysbiosis and the incidence of endometriosis, namely an increase in Bacteroidetes and a decrease in Firmicutes Keywords: endometriosis, dysbiosis, bacteroides, firmicutes, gut microbiota
Co-Authors Andani Eka Putra Fachry Abda El Rahman Nur Indrawaty Lipoeto Putri, Mentari Faisal Shreshta Dewi Utama, Bobby Indra