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All Journal Jurnal Gizi dan Pangan Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Adhani, Zalsabila Tiara
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Adherence to the Mediterranean Diet for a Better Sperm Quality: A Comprehensive Systematic Review and Meta-Analysis Munawwir, Abdul; Adhani, Zalsabila Tiara
Jurnal Gizi dan Pangan Vol. 20 No. 1 (2025)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2025.20.1.61-70

Abstract

The aim of this study is to investigate whether a higher adherence to the Mediterranean Diet (MD) can enhance reproductive indicators in infertile men. A comprehensive review and meta-analysis were conducted to assess whether increased adherence to the MD can enhance reproductive indicators in infertile men. An extensive search was conducted for pertinent studies in PubMed, Medline, and Google Scholar. The search included relevant publications published in the last 10 years from 2015. The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) 2020 instrument was used to evaluate the studies. The study's quality was evaluated using the Newcastle-Ottawa Scale (NOS). The data were analyzed and evaluated using RevMan version 5.4.1. The data on sperm volume were not statistically significant. The meta-analysis indicated an odds ratio of 1.06 for low semen volume (<1.5 mL) associated with low adherence to the MD (I2=12%; 95% CI:0.59–1.93, p=0.84). Furthermore, the analysis revealed a 2.86-fold increase in the probability of achieving higher sperm concentration (>15 × 106/mL) in individuals who adhered to the MD (I2=33%; 95% CI:1.58–5.18, p=0.0005). The meta-analysis further suggests that adherence to the MD is associated with a 2.54-fold increase in the likelihood of improving sperm count (>39 × 106/ejaculate) (I2=48%; OR=2.54; 95% CI:1.32–4.90, p=0.005). The meta-analysis on sperm motility demonstrated that individuals who adhere strictly to the MD are more likely to exhibit normal motility (>40%) (I2=0%; OR=4.64; 95% CI:2.41–8.95, p<0.00001). The meta-analysis further revealed a 2.66-fold increased likelihood of better sperm morphology (>4%) (I2=0%; OR=2.66; 95% CI:1.39–5.10, p=0.003) in individuals adhering to the MD. The present systematic review with meta-analysis indicates that higher adherence to the MD is associated with improved sperm quality parameters (sperm count, sperm concentration, sperm motility, and sperm morphology).
ASSOCIATION BETWEEN VITAMIN D RECEPTOR GENE POLYMORPHISM AND RENAL CALCIUM STONES : A LITERATURE REVIEW Adhani, Zalsabila Tiara; Munawwir, Abdul; Sabir, M.
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 2 (2024): Oktober
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i2.1571

Abstract

ABSTRAK Latar Belakang : Penyakit batu ginjal (nefrolitiasis) mempengaruhi hampir semua populasi di seluruh dunia dengan prevalensi yang terus meningkat. Beberapa penelitian menunjukkan reseptor vitamin D (VDR) berkorelasi dengan pembentukan batu kalsium ginjal. Tujuan penulisan artikel ini adalah untuk menemukan hubungan antara polimorfisme gen reseptor vitamin D (VDR) terhadap pembentukan batu kalsium ginjal dengan melakukan tinjauan literatur terhadap penelitian sebelumnya sesuai dengan kriteria yang ditetapkan. Metode : Pencarian literatur dilakukan melalui beberapa database jurnal internasional yaitu Pubmed dan Google Scholar. Pencarian ini bertujuan untuk menemukan literatur yang berkaitan dengan polimorfisme reseptor vitamin D (VDR) dan batu kalsium ginjal. Pencarian literatur dilakukan dengan menggunakan kata kunci “vitamin D receptor polymorphism” dan “calcium renal stone”. Kami menetapkan kriteria inklusi dan ekslusi pada penelitian ini kemudian melakukan peninjauan literatur secera komprehensif terhadap penelitian yang relevan. Hasil : Kami melakukan peninjauan terhadap 10 artikel ilmiah yang memenuhi syarat dan telah menemukan hubungan antara VDR gen polimorfisme (ApaI, BsmI, FokI, and TaqI) terhadap pembentukan batu kalsium ginjal pada manusia. Kesimpulan : Terdapat hubungan antara VDR gen polimorfisme (ApaI, BsmI, FokI, and TaqI) terhadap pembentukan batu kalsium ginjal pada manusia. ABSTRACT Background : Kidney stone disease (nephrolithiasis) affects almost all populations worldwide with an increasing prevalence. Several studies have shown that vitamin D receptor (VDR) is correlated with renal calcium stone formation. The purpose of writing this article is to find the relationship between vitamin D receptor (VDR) gene polymorphisms and renal calcium stone formation by conducting a literature review of previous studies according to established criteria. Methods : Literature search was conducted through several international journal databases, namely Pubmed and Google Scholar. This search aims to find literature related to vitamin D receptor (VDR) polymorphisms and kidney calcium stones. The literature search was conducted using the keywords “vitamin D receptor polymorphism” and “calcium renal stone”. We set inclusion and exclusion criteria for this study and then conducted a comprehensive literature review of relevant studies. Results: We reviewed 10 eligible scientific articles and found an association between VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) and calcium renal stone formation in humans. Conclusion : There is an association between VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) and kidney calcium stone formation in humans.
Co-Authors M. Sabir Munawwir, Abdul