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All Journal Indonesian Journal of Biomedicine and Clinical Sciences
Anton Darmawan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation between D-dimer and first-ever acute ischemic stroke (AIS) severity in Dr. Sardjito General Hospital, Yogyakarta Abdul Gofir; Hiztien Fahrurriza; Yudhanto Utomo; Amelia Nur Vidyanti; Anton Darmawan
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 1 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i4.16770

Abstract

Acute ischemic stroke (AIS) continuing to be an entity causing morbidity and mortality worldwide. The National Institutes of Health Stroke Scale (NIHSS) is a largely used as clinical assessment instrument to measure neurological deficit of stroke. Studies concerned that D-dimer, a fibrin degradation product, has as a potential biomarker in predicting stroke severity and prognosis. This study aimed to investigate the correlation between D-dimer levels and NIHSS score in patients with a first-ever AIS. This cross-sectional study used the stroke registry data of the Dr. Sardjito General Hospital, Yogyakarta from October 2021 to December 2022. A total 83 patients who met the inclusion and exclusion criteria were involved. The blood D-dimer level was measured during admission. The NIHSS scores were assessed within 24 hr of admission. The correlation between D-dimer levels and NIHSS scores were analysed using Spearman’s test. Multiple analysis was performed to evaluate the association of non-dependent risk factors using multiple logistic regression. The mean age of subjects was 60.77±11.08 yr, with a slightly males predominant (54.2%). The mean value of NIHSS score was 6.59 ± 7.00 and D-dimer level was 712.02 ± 1159.2 ng/mL. A significant positive correlation between D-dimer and NIHSS score (r= 0.475; p= 0.01) was observed. Furthermore, D-dimer remained showing an independent association with on-admission NIHSS score (p= 0.026). In conclusion, D-dimer level in stroke patients is associated with more severe on-admission NIHSS score.
Co-Authors Abdul Gofir Amelia Nur Vidyanti Hiztien Fahrurriza Yudhanto Utomo