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All Journal Asian Journal of Health Research
Hermanto TJ
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The cerebrum and cerebellum of Rattus norvegicus offspring, whose mothers were exposed to a sequence of 14 Mozart compositions during pregnancy, expressed higher levels of BDNF and dendritic density, but not mTORC1 Hermanto TJ; N Cininta M; Widjiati
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.212

Abstract

Introduction: To investigate Brain-Derived Neurotrophic Factor levels, Mammalian Target of Rapamycin Complex 1 levels, and Dendritic Density in the cerebrum and cerebellum of Rattus norvegicus offspring following prenatal Mozart compositions exposure. Material and Methods: An experimental study with a randomized post-test-only control group design was conducted at the Animal Laboratory of the Faculty of Veterinary Medicine, Universitas Airlangga, following ethical clearance. A 13 healthy pregnant female Rattus norvegicus were randomly chosen and exposed to 14 Mozart compositions, beginning on gestation day 10 until delivery, while another 13 served as the control group. At day 20, the rats were sacrificed, 2 offsprings' brains (the heaviest) were extracted, and BDNF levels were analyzed using the ab203573 immunohistochemistry kit, mTORC1 levels using the pSer2448 kit, and Dendritic Density using silver impregnation. Statistical analysis was performed accordingly with a significance level of p < 0.05. Results: BDNF levels and Dendritic density in the cerebrum of the treatment group were higher (2.27 ± 1.41 vs. tr 7.44 ± 2.09, p < 0.05) and (4.42 ± 2.04 vs. 6.67 ± 1.23, p < 0.05). In the cerebellum, BDNF levels and Dendritic density in the treatment group were higher (1 vs. 8, p < 0.05) and (3.34 ± 1.94 and 7.91 ± 2.45, p < 0.05). mTORC1 levels in the treatment group were lower but not statistically significant in both areas. Conclusion: Prenatal 14 Mozart compositions exposure during pregnancy increased Rattus norvegicus offsprings' cerebrum and cerebellum BDNF levels and Dendritic Density. A correlation was found between BDNF levels and dendritic density.
D4P4: A Neuro-Pedagogic Model for Developing High-Risk/ High-Precision Procedural Skills in Residency Training Hermanto TJ
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.274

Abstract

Medical education stands at a pivotal juncture. The long-standing "see one, do one, teach one" model, once the cornerstone of clinical training, is increasingly inadequate for preparing today’s physicians. Rising resident-to-patient ratios, overwhelmed faculty, and the distinct learning preferences of Generation Z demand a more sophisticated and responsive approach. In response to these challenges, the D4P4 model emerges as a transformative framework—rooted in decades of neuroscience and educational theory—designed to cultivate high-risk, high-precision procedural skills in residency programs..
Do Medicine and Medical Education Need a Paradigm Shift? Hermanto TJ
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.300

Abstract

Modern medicine stands at a crossroads. The Human Genome Project and the Decade of the Brain have revealed the profound biological and neurological individuality of every human being. Yet paradoxically, clinical practice and medical education continue to operate as if one method fits all. Patients are often reduced to diagnostic codes and treatment algorithms, while students are molded through standardized curricula, uniform assessments, and teacher-centered instruction. The result is a dissonance between what science now knows, that every brain and body is unique, and how medicine is still practiced and taught. Half a century ago, Ivan Illich, in Medical Nemesis, warned of the medicalization of life where health becomes a commodity and suffering a pathology. Today, his warning resounds in the rising prevalence of iatrogenic conditions, from overtreatment to complex disorders such as placenta accreta syndrome. Bernard Lown in The Lost Art of Healing, lamented the erosion of empathy, while Atul Gawande’s Being Mortal reminds us that extending life is not the same as healing it. These critiques echo Sir William Osler’s timeless insight: that the good physician treats the disease, but the great physician treats the patient who has the disease.
Co-Authors N Cininta M Widjiati